-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
| The latest international research: an Alzheimer's disease vaccine shows safety and immune response |
Chinanews.
com, Beijing, June 15 (Reporter Sun Zifa) Springer Nature’s professional academic journal "Nature-Aging" recently published a medical research paper saying that researchers are targeting Alzheimer’s disease commonly known as Alzheimer’s.
The results of phase 2 clinical trials of a vaccine developed by AD) show that this vaccine named AADvac1 is safe and can induce an immune response in patients with mild Alzheimer's disease
.
However, the paper also reminded that researchers could not detect the specific impact of the AADvac1 vaccine on patients' cognitive decline
.
The paper introduced that the toxic form of tau protein would accumulate and spread in the brains of patients with Alzheimer's disease, which is also a pathological feature of the disease
.
This protein is thought to cause a large number of neuronal deaths and eventually cause dementia
Corresponding author of the paper, Petr Novak of AXON Neuroscience Customer Relationship Management Service in Bratislava, Slovakia, and colleagues conducted a phase 2 randomized placebo-controlled trial, enrolling 196 mild Alz Patients with Haimer disease (mean age 71.
4 years; 45.
1% male; 100% white)
.
The researchers injected multiple doses of a polypeptide vaccine called AADvac1 or a placebo for these patients, and monitored the safety, immunogenicity (that is, the ability of the vaccine to induce an immune response) and clinical efficacy of the vaccine over a period of two years
The authors of the paper generally concluded that although patients have a good tolerance to AADvac1 and can produce an immune response to tau protein, the vaccine cannot produce statistically significant cognitive benefits.
This may be due to the lack of tau protein pathology in some patients.
Performance, or because the sample size of the study is small
.
Therefore, follow-up still needs to conduct a larger-scale stratified test based on the existence of disease biomarkers, repeat the above research results and fully evaluate the possible clinical efficacy of AADvac1
