Alzheimer's & Dementia: To what extent can interventions achieve maximum cognitive improvement

Little is known about the dose-response function in multidomain interventions to prevent
dementia .

Dose is a key factor examined in pharmacological treatments, but little is known about the dose effects of non-pharmacological multidomain interventions and the optimal dose or mathematical functions associated with dose improvement

prevention

Sylvie Belleville et al.
published a research article in the journal Alzheimer's & Dementia, using data from the MAPT study to model the relationship between dose and cognitive improvement in a multi-domain intervention and determine the optimal dose
.

The Multidisciplinary Alzheimer's Prevention Trial is a 3-year randomized controlled trial including cognitive training, physical activity, nutrition and older adults at risk for omega-3 polyunsaturated fatty acids
.

The doses provided (number of sessions attended) were modeled on the overall cognition, memory and fluency of the 749 participants

Key Findings and Explanations on Enhancement and Maintenance Models

Key Findings and Explanations on Enhancement and Maintenance Models

Scatter plot of total training dose versus overall cognitive change score: (A) main effect; (B) interaction with frailty
.

Scatter plot of total training dose versus overall cognitive change score: (A) main effect; (B) interaction with frailty
.

Scatter plot of total training dose effect on delayed memory change scores: (A) main model; (B) interaction with age
.

Scatter plot of total training dose effect on delayed memory change scores: (A) main model; (B) interaction with age
.

Scatter plot of total training dose effect on verbal fluency change scores: (A) main effects and interactions with gender (B), education level (C), and dementia risk score (D)

Scatter plot of total training dose effect on verbal fluency change scores: (A) main effects and interactions with gender (B), education level (C), and dementia risk score (D)

Distribution plots of change scores (residuals) for overall cognition, delayed memory, and verbal fluency
.

Distribution plots of change scores (residuals) for overall cognition, delayed memory, and verbal fluency
.

The dose-response model was a nonlinear function, indicating benefit after 12 to 14 hours or 15 to 20 multi-domain training sessions, followed by a plateau
.

Participants who benefited from the higher dose included women, younger participants, frail individuals, and those with less education or a lower risk of developing dementia

Benefit can be obtained after 12 to 14 hours or 15 to 20 sessions of multi-domain training, followed by a plateau in multi-domain intervention, where higher doses are not necessarily better

The optimal intervention dose is 12 to 14 hours of training, which is about half the dose that participants may get The optimal intervention dose is 12 to 14 hours of training, which is about half the dose that participants may receive Different individuals benefit from different doses

original source

Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia

Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementiaLeave a comment here