 Home > Active Ingredient News > Study of Nervous System > Alzheimer's & Dementia: Head injury is related to tau deposition in the brains of MCI and AD patients

Alzheimer's & Dementia: Head injury is related to tau deposition in the brains of MCI and AD patients

 Last Update: 2021-09-04
 Source: Internet
 Author: User

Tags

research chemicals

baker test

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Statistics show that Alzheimer's disease (AD) affects more than 5.

Traumatic brain injury (TBI) associated with head injury (HI) is a risk factor for dementia, including AD and other neurodegenerative diseases

Traumatic brain injury (TBI) related to head injury (HI) is a risk factor for dementia, including AD and other neurodegenerative diseases Traumatic brain injury (TBI) related to head injury (HI) is a risk factor for dementia, including AD And other neurodegenerative diseases

Neuroimaging studies of TBI patients showed abnormal white matter microstructures, as well as gray matter and white matter atrophy in symptomatic CTE patients

A study using [18F]flortaucipir tau PET on small samples of suspected CTE and/or other recurring HI due to exercise or military exposure showed that [18F]flortaucipir combined with the frontal, occipital, and temporal lobes in the subcortical area Increase

Currently, the potential link between head injury (HI) and dementia is not entirely clear

Recently, researchers used amyloid and [18F] fluorouracil positron emission tomography, HI history data, Alzheimer’s Disease Neuroimaging Initiative, and the Indiana Memory and Aging Research Cognitive Test to test 752 subjects Cognition and tau deposition were compared, of which 302 had cognitive impairment and 450 had no cognitive impairment (CN)

According to the diagnosis Tau deposition of the population and a history of head injury

According to the diagnosis deposition of Tau population and a history of head injuries based on diagnosis deposition of Tau population and a history of head injury diagnosis

In this study, 63 people (38 CN, 25 impaired) reported a history of HI

It has been observed that people with a history of HI have higher neuropsychological scores and poor memory

Biological changes, such as more tau, are related to the history of HI in people with cognitive impairment.

Original source:

Shannon L.

Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.