Alzheimers Dementia: Cardiovascular risk factors are highly correlated with the risk of dementia

Many studies have investigated the single heart vascular risk factors, including age, diabetes , high blood pressure, smoking and high cholesterol influence of hyperlipidemia risk of dementia, the results are not the same
.

Heart vascular diabetes cholesterol

In view of the fact that these cardiovascular risk factors cluster and interact in individuals, if a multivariate risk prediction algorithm including these risk factors is used to explore the overall impact of cardiovascular risk burden on dementia, the effect will be better
.

The Framingham General Cardiovascular Risk Score (FGCRS) is a predictive algorithm that assesses cardiovascular risk by combining demographics (ie age and gender) with traditional cardiovascular risk factors Burden and risk of cardiovascular disease (CVD)
.

FGCRS is associated with cognitive decline, and other studies have used different comprehensive scores (including FGCRS and dementia risk scores) that summarize vascular risk factors to predict the risk of dementia
.

However, the relationship between the combination of multiple vascular risk factors (such as FGCRS) and the risk of Alzheimer's disease (AD) dementia is still uncertain

Although the cardiovascular risk burden is an important goal in preventing dementia, the mechanism of this association is not well understood
.

In aging and dementia research, neuropathological evaluation usually includes a unified and structured evaluation of AD pathology, vascular pathology, Lewy body disease, and other pathologies

prevention

Some neuropathological studies focused on individual cardiovascular risk factors and brain diseases, and there were inconsistent findings
.

Few studies have shown the relationship between diabetes or hypertension and AD pathology (such as neuronal plaques and neurofibrillary tangles)

Invest in research to explore diabetes, hypertension or Framingham stroke risk scale (including age, systolic blood pressure, current smoking status, antihypertensive drug use, epidemic diabetes, epidemic cardiovascular disease and epidemic atrial fibrillation) and cerebrovascular disease (including Cortical infarction and arteriosclerosis stage), but did not explore the relationship with AD pathology
.

Therefore, the relationship between vascular risk burden and brain pathology, especially the relationship with AD pathology, needs to be further clarified in a cohort study of people with neuropathological examination
.

The relationship between vascular risk burden and brain pathology, especially the relationship with AD pathology, needs to be further clarified in a cohort study of people with neuropathological examination
.

The relationship between vascular risk burden and brain pathology, especially the relationship with AD pathology, needs to be further clarified in a cohort study of people with neuropathological examination

They used the Rush Memory and Aging Project (Rush Memory and Aging Project).
A total of 1,588 participants without dementia underwent FGCRS assessment at baseline and followed up for 21 years
.

During the follow-up period, 621 participants died and underwent an autopsy

They found that the multiple adjusted hazard ratios (HRs) of FGCRS were 1.
03 (1.
00-1.
07) for dementia and 1.
04 (1.
01-1.
07) for Alzheimer's disease (AD) dementia
.

The multiple adjusted hazard ratios (HRs) of FGCRS are 1.
03 (1.
00-1.
07) for dementia and 1.
04 (1.
01-1.
07) for Alzheimer's disease (AD) dementia
.

The multiple adjusted hazard ratios (HRs) of FGCRS are 1.

The important significance of this study is that it found that higher FGCRS is associated with an increased risk of dementia and AD dementia
.

Both blood vessels in the brain and AD lesions may be the basis of this association

 

Original source:
Song R, Pan K, Xu H, et al.

Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population‐based cohort study.

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