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There is increasing evidence that adherence to a healthy life>
.
Studies have shown that people with four or five health factors, such as physical and cognitive activities, eating high-quality diets, non-smoking and restricting alcohol, are more likely to suffer from AD dementia than those with <=1 health factor The risk is 60% lower
.
At the same time, some clinical trials are being conducted around the world (WorldWide FINGERS), including US POINTER in the United States, to determine the causal inferences of life>preventing AD dementia in the elderly
.
The positive findings of these clinical trials are extremely important for public health, because in the absence of treatment, these interventions will help prevent cognitive impairment in the vulnerable population of the elderly
.
However, in general, a feature of primary prevention clinical trials is that it is difficult to recruit different populations, especially African Americans
For example, the incidence of AD dementia among African Americans is two to three times higher than that of European Americans, although their cognitive decline is at a similar or slower rate
.
In addition, the prevalence of lipoprotein E (APOE) 4 alleles in African Americans is higher than that in European Americans, and APOE is a genetic risk factor for dementia
In this way, Klodian Dhana and others of Rush University Medical Center used The Chicago Health and Aging Project (CHAP) to explore genetic risks and life>
.
This study also explored the relationship between life>
.
.
Explored the relationship between life>
Using data from the Chicago Health and Aging Project (1993-2012; n=3874), they defined genetic risk based on the presence of the lipoprotein E (APOE) ε4 allele, and used five-factor scores to determine health Life>
.
Finally, a linear mixed-effects model was used to estimate genetic risk and cognitive decline in life>
They found that the APOE ε 4 allele was associated with faster cognitive decline in the two races
.
However, among APOE ε 4 carriers, adherence to a healthy life>
.
The significance of this study lies in the findings: In African Americans and European Americans, healthy life>
.
.
In African Americans and European Americans, a healthy life>
Original source:
Dhana K, Barnes LL, Liu X, et al.
Genetic risk, adherence to a healthy life>Leave a message here