Alzheimers Dement: Middle-aged and elderly men with lower serum testosterone levels have a higher risk of developing dementia

As men age, testosterone levels decrease, partly because of the relative increase in central obesity and the accumulation of medical comorbidities
.
Some longitudinal studies in men have shown that when the testosterone concentration is reduced or lowered, the memory decreases and the risk of dementia increases

Bu B.
Yeap et al .
published a research article in the journal Alzheimers Dement , studying the relationship between serum testosterone and sex hormone binding globulin (SHBG) and the incidence of dementia and Alzheimer's disease
.

They used immunoassay to determine serum total testosterone and SHBG

Among the 159,411 community men (median age 61 years, follow-up for 7 years), 826 developed dementia, of which 288 had AD
.

Lower total testosterone and higher dementia (overall trend: P = 0.
001, lowest and highest quintile: hazard ratio [HR] = 1.
43, 95% confidence interval [CI] = 1.
13-1.
81) and AD (P = 0.
017, HR = 1.
80, CI = 1.
21-2.
66) incidence is related
.

Multivariate model of the effect of baseline total testosterone concentration on the occurrence of (A) dementia and (B) Alzheimer's disease, which controls additional risk factors and confounding factors

Lower SHBG is associated with lower incidence of dementia (P <.

A multivariate model of the effect of baseline SHBG concentration on events (A) dementia and (B) Alzheimer's disease, which controls for additional risk factors and confounding factors
.

Middle-aged and elderly men with lower testosterone levels have a higher risk of dementia and Alzheimer's disease

Original source

Marriott RJ, Murray K, Flicker L, et al.