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Alzheimer's cognitive decline "culprit" revealed

 Last Update: 2022-03-03
 Source: Internet
 Author: User

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According to a study published in the journal Alzheimer's Disease and Dementia on the 17th, advanced imaging technology developed by Yale University researchers helped them confirm that the destruction of brain synapses is a key factor in cognitive impairment in Alzheimer's patients.

Scientists have believed for years that the loss of connections between brain cells leads to Alzheimer's-related symptoms, including memory loss, but the actual evidence for the effects of the loss of brain synapses has been limited to the middle and late stages.

PET imaging scans of the new glycoprotein 2A (SV2A) allowed scientists to measure the metabolic activity of brain synapses in 45 people diagnosed with mild to moderate Alzheimer's disease

They found that loss of synapses, or connections, between brain cells was strongly associated with poor performance on cognitive tests

Researchers can now track patients' loss of synapses over time to better understand individual cognitive decline, said Christopher Van Dyke, director of the Yale Alzheimer's Disease Research Center and senior author of the paper.

"These findings help us understand the neurobiology of the disease and could be important new biomarkers for testing the efficacy of new Alzheimer's drugs," said lead author Don McCain

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New Yale imaging scans reveal culprit for cognitive decline in Alzheimer's

03-02

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Alzheimer's cognitive decline "culprit" revealed

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New Yale imaging scans reveal culprit for cognitive decline in Alzheimer's