Alzheimer's brain activity and brain network abnormalities can be accurately depicted

Alzheimer's disease (AD) is an irreversible neurodegenerative diseasesBased on a large number of studies suggest that AD functional magnetic resonance imaging may be a connection failure syndromeHowever, due to the lack of a large sample, multi-site cross-validation data set so far and AD brain function activity, abnormal pattern of brain connection has not been a clear and consistent conclusion, whether the AD brain function activity can be used as an early radiographic markers has yet to be further verificationaccurately portray AD brain activity, abnormal patterns of brain and brain network connection, and functional magnetic resonance imaging to explore the feasibility of early AD index as an identification mark, Institute of Automation network Brain Research Center researchers joint Chinese PLA General hospital, Xuanwu hospital, capital Medical University, Tianjin Lake hospital and Qilu hospital of Shandong University and other domestic and foreign institutions which make up the research team, joint use functional magnetic resonance imaging data multi-center, large sample ( N = 688), a method using meta-analysis found in AD stable, repeatable pattern dysfunction, and parsing the generalized individualized diagnosis precisionfeasibility and biological mechanisms labeled other aspects of the research systemThe study, recently published in the "
HumanBrainM apping" onlineThis is the first multi-center, large sample resting state functional magnetic resonance dataset functional abnormalities of AD patients were studied systematically and to assess the function abnormality associated with AD as AD effectiveness and generalized diagnostic biomarkersofMore specifically, the default network found in the brain (the DMN), cingulate cortex, basal ganglia and the hippocampus in connection with abnormal function and activity may be partial AD cognitive ability, information exchange Brain damaged foundationThe severity of abnormal brain network of inter-individual differences in the degree of cognitive impairment, the cumulative level of β-amyloid significantly correlated, which further deepened the understanding of the relationship between our neurobiological basis of brain function and activity of AD exceptionCross-center independent verification of individual recognition accuracy and clinical score prediction results show that the functional activity of brain abnormalities may develop possible radiological markers as AD happenSubsequent independent validation data set and a series of comparative experiments confirmed the reproducibility of the results and generalized, tamp conclusionwhich is the Alzheimer's research team following functional magnetic resonance imaging brain activity change multi-center study on AD hippocampus and early identification of genomics-based imaging, characterized in brain imaging abnormalities of AD another important progress madeTeam follow-up work will focus on more independent centers, validation longitudinal tracking of high-risk groups, and hope that more teams to establish further cooperation The research was supported by key national research and development program topics, the National Natural Science Foundation of surface project, a pilot project Chinese Academy of Sciences and National Laboratory of Pattern Recognition open projects and other projects (A Biovalley Bioon.com)