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With the aging of the population and the increase in life expectancy, the burden of Alzheimer's disease and related dementia (ADRD) has increased exponentially, and people are paying more and more attention to identifying modifiable factors to delay or prevent the onset
Prevention but ADRD one-third of cases are preventable, heart vascular (CV) risk factors are also promising prevention targets
Middle-aged CV risk factors are related to cognitive impairment and dementia in later life, and may be more predictive of cognitive impairment and dementia in the elderly than risk factors measured in old age
However, there are currently few studies investigating the relationship between CV risk factors and cognitive changes in middle age
Middle-aged CV risk factors are related to the risk of old age dementia and related dementia
Researchers used data from the National Women’s Health Study to study middle-aged hypertension, elevated blood lipid levels, diabetes , fasting blood sugar, central obesity, and Framingham heart disease.
diabetes
Flow chart for analyzing samples
The results showed that compared with patients with healthy CV, patients with central obesity (60.
Compared with patients with healthy CV, patients with central obesity (60.
Estimated SDMT score based on CV exposure status
For SDMT, the model shows that the processing speed is lower than the subsequent ones, with an average change of 0.
After adjusting for other covariates, this trend persisted
It can be seen that middle age may be a critical period for intervention of cardiovascular risk factors to prevent or delay cognitive impairment and ADRD in later life
references:
Cardiovascular risk and midlife cognitive decline in the Study of Women's Health Across the Nation.
Cardiovascular risk and midlife cognitive decline in the Study of Women's Health Across the Nation.
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