-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Recent research has focused on developing blood biomarkers for neurodegenerative diseases, and these efforts have yielded important progress
.
Cerebrospinal fluid (CSF) biomarkers and amyloid β (Aβ) positron emission tomography (PET) remain established tests
to support in vivo diagnosis of AD.
It has been suggested that a direct comparison of the main blood phosphorylated tau immunoassays in the memory outpatient population is needed to understand possible differences
.
Therefore, scholars from Sweden carried out relevant research
.
In the BIODEGMAR study, 197 participants with cognitive problems were divided into Alzheimer's disease (AD) and non-AD cerebrospinal fluid (CSF) data groups
based on the ratio of amyloid β42/phosphorylated tau (Aβ42/p-tau).
The researchers performed head-to-head comparisons of 9 plasma and 9 CSF tau immunoassays and determined their accuracy
for discriminating abnormalities in CSF Aβ42/p-tau ratios.
The results showed that all studied plasma tau biomarkers were significantly higher in the AD CSF lineage group than in the non-AD CSF lineage group, and the abnormal CSF Aβ42/p-tau ratio
could be significantly identified.
For plasma p-tau biomarkers, Janssen p-tau217 (r=0.
76; area under the curve [AUC]=0.
96), ADx p-tau181 (r=0.
73; AUC=0.
94) and Eli Lilly p-tau217 (r=0.
73; AUC=0.
94) had high
identification accuracy.
It follows that several plasma p-tau biomarkers can be used as independent biomarkers in specialized memory clinics to detect biodefined AD
.
References:
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays.
https://doi.
org/10.
1002/alz.
12841