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Alzheimer Dementia: APOE ε4 carrier with normal cognitive performance, neural network disorder

 Last Update: 2021-08-01
 Source: Internet
 Author: User

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Apolipoprotein E (APOE) ε4 allele status is still the most common genetic risk factor that changes the risk of Alzheimer's disease (AD) in individuals
.

The presence of a single APOE ε4 allele increased the risk of AD by ≈3.

However, it is still unclear which factor or combination of these factors is the main event leading to the destruction of early microcells, which may be manifested as a macro-scale reorganization of functional connections within and/or between key brain regions
.

Regions in the brain show coherent activities in different functional and cognitive areas, forming a basic network, which is preserved in different individuals
.

In AD, network reorganization may occur at different spatial scales, affecting local and long-distance connections

The prerequisite for evaluating apoE-mediated cortical reorganization and subthreshold amyloid burden is to be able to appropriately select high-risk individuals with normal cognition
.

The biomarker profile determined by molecular imaging of cerebrospinal fluid (CSF) and PET can be used to stratify the target population

Biomarkers can quantify an individual's A-beta and tau burden, allowing direct comparison with the macro-scale reorganization of rs-fc indicators in key brain networks

The significance of this study lies in the discovery that APOE ε4 carriers with normal cognition have subthreshold amyloid accumulation, which may involve tau-related network reorganization
.

It was found that APOE ε4 carriers with normal cognition had subthreshold amyloid accumulation, which may involve tau-related network reorganization
.

It was found that APOE ε4 carriers with normal cognition had subthreshold amyloid accumulation, which may involve tau-related network reorganization

Original source:

Butt OH, Meeker KL, Wisch JK, Schindler SE, Fagan AM, Benzinger TLS, Cruchaga C, Holtzman DM, Morris JC, Ances BM.

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