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Alz Res Therapy: Genetic risk score is closely related to phosphorylated tau protein in the blood

 Last Update: 2021-11-11
 Source: Internet
 Author: User

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The neuropathological features of Alzheimer's disease (AD) are determined by the aggregation of amyloid β (Aβ) protein into plaques and the hyperphosphorylation of tau protein and the formation of neurofibrillary tangles

diagnosis

The emergence of cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers is very important for clinical and research work in this field

Therefore, there is a great need for more easily available biomarkers, such as those measured in plasma

The purpose of this study is to investigate the relationship between AD-PRSs (with and without APOE) and plasma p-tau181 in ADNI study participants

Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) was used to study the relationship between AD PRS (constructed based on the results of a recent genome-wide association study) and plasma p-tau181, using a linear regression model

In the total sample, there was an association between plasma p-tau181 and APOE PRS (p=3e-18-7e-15) and non-APOE PRS (p=3e-4-0.

APOE PRSs showed similar results in amyloid β (Aβ)-positive and negative individuals, while non-APOE PRSs were only associated with plasma p-tau181 in Aβ-positive individuals (p = 0.

The important significance of this study lies in the discovery: AD polygenic risk including APOE is related to plasma p-tau181, not related to diagnosis and Aβ pathological state , and AD polygenic risk other than APOE is only related to MCI and Aβ positive patients.

The risk of AD polygenic, including APOE, is related to plasma p-tau181, but not related to diagnosis and Aβ pathology

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