Alternatives to forage antibiotics

the use of antibiotics forwas once considered the greatest biotechnology in livestock production in the 20th centurySince streptomycin was first reported in 1946 to stimulate chick growth, and in 1950 the U.SFood and Drug Administration (FDA) approved antibiotics as feed additives, antibiotics in a large number of treatments and prevention of bacterial diseases, but also as a feed additive saucy and widespread promotion and applicationiDQ
However, with the long-term high-dose abuse of antibiotics, as well as the feeding of antibiotics more in-depth research, its disadvantages are gradually recognizedEspecially in recent years, the incidents caused by feed safety issues have attracted more and more people's attention around the world, and the addition of antibiotics in feed has also been opposed by more and more scientists and livestock workersiDQ
In general, long-term large-scale use of feed antibiotics as feed additives, will lead to the following negative effects: 1, the production of drug-resistant strains;iDQ
Based on the shortcomings of the long-term use of antibiotics, alternatives to forage antibiotics have become one of the most popular keywords in the field of animal husbandry in recent yearsTo sum up, there are the following kinds of alternatives to forage antibiotics on the market: antimicrobial peptides, organic acids, enzymes, oligosaccharides, herbal medicines, micro-ecological preparations, among these six alternatives, the most promising is currently recognized as antimicrobial peptide productsiDQ
　　As an important component of animal and plant defense system, antimicrobial peptides have the advantages of good stability, green safety, broad spectrum sterilization and so on, and are obviously better than traditional antibiotics in terms of not easily developing resistance With the deepening of modern science's understanding of the relationship between the structure and activity of antimicrobial peptides, the mechanism of action of antimicrobial peptides and the mechanism of gene expression regulation, it is proved to be completely feasible to produce an efficient, environmentally friendly antimicrobial peptide with genetic engineering methods, which is beneficial to animal and human health, making it a substitute for antibiotics iDQ
　　However, when antimicrobial peptides into the field of animal husbandry, on the one hand, due to the maturity of the corresponding technology must go through a certain process, on the other hand, because of the good market prospects of antimicrobial peptides, so that the market for a time there are many kinds of "antibacterial peptides", which gives the vast number of farmers (southern rural report agricultural financial report new pastoral network) practitioners brought confusion and confusion, think that the antibacterial peptide effect is slow, the results are not significant, more afraid to replace antibiotics iDQ
　　San Sima Biotechnology Co., Ltd as the world's first specialized in the research and development and transformation of antimicrobial peptide technology, since the beginning of the field of antimicrobial peptides, will replace antibiotics, improve the overall health of pigs as the main line of product research and development In 8 years of effective in-depth research and technical applications, not only established the leading position of enterprises in the field of international antimicrobial peptides, but also through bioinformatics analysis methods, the current known more than 4000 kinds of antimicrobial peptides for classification and analysis, the establishment of a complete antimicrobial peptide gene bank At present, 10 antimicrobial peptide gene engineering bacteria have been successfully constructed, 6 of which have been successfully applied in industrialization iDQ
　　On the other hand, San Sima also actively carried out various domestic and foreign cooperation exchanges, through a large number of field trials and standard research test data, proved that the replacement of antibiotics with San Sima antimicrobial peptides is completely feasible iDQ
　　Especially in the replacement of antibiotics with antibiotics and the improvement of the overall health of pigs, San Sima and Chulalongkorn University in Thailand have been conducting high-end international cooperation for nearly two years since 2010, and have completed four standardized trials to further lift the "mystery" of antimicrobial peptides The test and the protection test for E coli disease in piglets have proved that the antimicrobial peptide products of San Sima are effective in improving piglet immunity, improving the growth performance of piglets, and resisting piglets' weaning stress syndrome, and also prove that San Sima antimicrobial peptides can effectively reduce the use of antibiotics and eliminate various negative effects of antibiotics iDQ
　　This set of data is not difficult to see, compared with antibiotics, lysozyme and cocchase, peptide easy group in reducing the meat ratio and increase the average daily weight gain are significantly better than the other groups Among them, by 1.5 kg / ton of the ratio of adding peptides easily can achieve the equivalent of adding antibiotics, adding 2-3kg / ton of peptides easy use effect is better than adding antibiotics In addition, E coli has a significant effect on the production performance of piglets (P 0.01), and peptides can easily effectively control the toxic effect of E coli on piglets iDQ
　　In 2012, San Sima Company also carried out on-site drug substitution and prevention of the disease of piglets in Zengcheng Chengxing pig farm and Shenzhen Agriculture and Livestock, through several repeated trials to further prove that in the current livestock breeding industry, San Sima antimicrobial peptides with its unique physical role and functional advantages, has become the preferred antibiotic substitute iDQ
　　From the above data, we can see that adding San Sima antimicrobial peptide san to normal pigletdiet can not only effectively replace antibiotics, so as to achieve the goal of increasing the average daily weight gain, reducing the ratio of meat and the incidence, and The antimicrobial peptides of San Sima are superior to antibiotics in the prevention of pig disease Long-term use, can significantly reduce the amount of drug and drug costs, eliminate drug hazards, can fundamentally improve the health level and growth performance of piglets, thus, in the livestock industry on the "no anti-resistance era" of the call is growing today, San Sima company with its own unique concept and way, with its own strong in the field of antimicrobial peptide technology and genetic engineering, to give antimicrobial peptide products more rich connotation, so that it fully shows the significant effect of alternative antibiotics, become the first choice of antibiotics iDQ the use of antibiotics for feeding was considered the greatest biotechnology in livestock production in the 20th century Since streptomycin was first reported in 1946 to stimulate chick growth, and in 1950 the U.S Food and Drug Administration (FDA) approved antibiotics as feed additives, antibiotics in a large number of treatments and prevention of bacterial diseases, but also as a feed additive saucy and widespread promotion and application iDQ
　　However, with the long-term high-dose abuse of antibiotics, as well as the feeding of antibiotics more in-depth research, its disadvantages are gradually recognized Especially in recent years, the incidents caused by feed safety issues have attracted more and more people's attention around the world, and the addition of antibiotics in feed has also been opposed by more and more scientists and livestock workers iDQ
　　In general, long-term large-scale use of feed antibiotics as feed additives, will lead to the following negative effects: 1, the production of drug-resistant strains; iDQ
　　Based on the shortcomings of the long-term use of antibiotics, alternatives to forage antibiotics have become one of the most popular keywords in the field of animal husbandry in recent years To sum up, there are the following kinds of alternatives to forage antibiotics on the market: antimicrobial peptides, organic acids, enzymes, oligosaccharides, herbal medicines, micro-ecological preparations, among these six alternatives, the most promising is currently recognized as antimicrobial peptide products iDQ
　　As an important component of animal and plant defense system, antimicrobial peptides have the advantages of good stability, green safety, broad spectrum sterilization and so on, and are obviously better than traditional antibiotics in terms of not easily developing resistance With the deepening of modern science's understanding of the relationship between the structure and activity of antimicrobial peptides, the mechanism of action of antimicrobial peptides and the mechanism of gene expression regulation, it is proved to be completely feasible to produce an efficient, environmentally friendly antimicrobial peptide with genetic engineering methods, which is beneficial to animal and human health, making it a substitute for antibiotics iDQ
　　However, when antimicrobial peptides into the field of animal husbandry, on the one hand, due to the maturity of the corresponding technology must go through a certain process, on the other hand, because of the good market prospects of antimicrobial peptides, so that the market for a time there are many kinds of "antibacterial peptides", which gives the vast number of farmers (southern rural report agricultural financial report new pastoral network) practitioners brought confusion and confusion, think that the antibacterial peptide effect is slow, the results are not significant, more afraid to replace antibiotics iDQ
　　San Sima Biotechnology Co., Ltd as the world's first specialized in the research and development and transformation of antimicrobial peptide technology, since the beginning of the field of antimicrobial peptides, will replace antibiotics, improve the overall health of pigs as the main line of product research and development In 8 years of effective in-depth research and technical applications, not only established the leading position of enterprises in the field of international antimicrobial peptides, but also through bioinformatics analysis methods, the current known more than 4000 kinds of antimicrobial peptides for classification and analysis, the establishment of a complete antimicrobial peptide gene bank At present, 10 antimicrobial peptide gene engineering bacteria have been successfully constructed, 6 of which have been successfully applied in industrialization iDQ
　　On the other hand, San Sima also actively carried out various domestic and foreign cooperation exchanges, through a large number of field trials and standard research test data, proved that the replacement of antibiotics with San Sima antimicrobial peptides is completely feasible iDQ
　　Especially in the replacement of antibiotics with antibiotics and the improvement of the overall health of pigs, San Sima and Chulalongkorn University in Thailand have been conducting high-end international cooperation for nearly two years since 2010, and have completed four standardized trials to further lift the "mystery" of antimicrobial peptides The test and the protection test for E coli disease in piglets have proved that the antimicrobial peptide products of San Sima are effective in improving piglet immunity, improving the growth performance of piglets, and resisting piglets' weaning stress syndrome, and also prove that San Sima antimicrobial peptides can effectively reduce the use of antibiotics and eliminate various negative effects of antibiotics iDQ
　　This set of data is not difficult to see, compared with antibiotics, lysozyme and cocchase, peptide easy group in reducing the meat ratio and increase the average daily weight gain are significantly better than the other groups Among them, by 1.5 kg / ton of the ratio of adding peptides easily can achieve the equivalent of adding antibiotics, adding 2-3kg / ton of peptides easy use effect is better than adding antibiotics In addition, E coli has a significant effect on the production performance of piglets (P 0.01), and peptides can easily effectively control the toxic effect of E coli on piglets iDQ
　　In 2012, San Sima Company also carried out on-site drug substitution and prevention of the disease of piglets in Zengcheng Chengxing pig farm and Shenzhen Agriculture and Livestock, through several repeated trials to further prove that in the current livestock breeding industry, San Sima antimicrobial peptides with its unique physical role and functional advantages, has become the preferred antibiotic substitute iDQ
　　From the above data, we can see that adding San Sima antimicrobial peptide san to normal pigletdiet can not only effectively replace antibiotics, so as to achieve the goal of increasing the average daily weight gain, reducing the ratio of meat and the incidence, and The antimicrobial peptides of San Sima are superior to antibiotics in the prevention of pig disease Long-term use, can significantly reduce the amount of drug and drug costs, eliminate drug hazards, can fundamentally improve the health level and growth performance of piglets, thus, in the livestock industry on the "no anti-resistance era" of the call is growing today, San Sima company with its own unique concept and way, with its own strong in the field of antimicrobial peptide technology and genetic engineering, to give antimicrobial peptide products more rich connotation, so that it fully shows the significant effect of alternative antibiotics, become the first choice of antibiotics iDQ