Allow animals to heat up and live longer, so that one amino acid can be corrected

Researchers at University College London (UCL) and the Institute of Medical Sciences London (MRC) found in simple biological models that reducing natural errors in protein synthesis (production) can improve health and longevity
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The new discovery, published in the journal Cell Metabolism, demonstrated for the first time a direct link between reduced protein errors and longevity
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The lead author of the study, Dr.
Ivana Bjedov (University College London Cancer Institute) explained: “We often hear that DNA mutations can cause cancer, which is considered to be one of the underlying causes of aging
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"However, protein errors that affect the body's health have been largely ignored, despite the fact that errors introduced during the synthesis of new proteins are more frequent than mutations during DNA replication
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"So, in this study, we focused on protein errors, and we questioned whether the reduction of protein errors can improve health
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In this study, the scientists investigated an evolutionary "super-precision" mutation called RPS23 K60R, which was found in the ribosome (the protein production factory of the cell) of thermophilic archaea, which is a kind of Single-celled organisms that can survive at extremely high temperatures
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Through genome editing, the scientists designed a metazoan ribosome to carry the same mutation (single amino acid change) as the hyperthermic archaea, thereby replicating its pair in simple model organisms, namely yeast, nematodes, and fruit flies.
The effect of protein synthesis
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The research team observed that the proteins of these organisms have fewer errors, so these organisms become heat-resistant and live longer
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First author Dr.
Victoria Eugenia Martinez-Miguel (University College London Cancer Institute) said: "The process of making proteins is not without errors-ribosomes can also make mistakes
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"We have shown for the first time that changing an amino acid in the decoding center of the ribosome can reduce protein synthesis errors and improve the body's ability to withstand stress and lifespan
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In addition to recombinant ribosomes, researchers have found that some drugs approved for use in humans can also reduce protein errors
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Co-corresponding author Professor Filipe Cabreiro (MRC London Institute of Medical Sciences) said: “This is the first study of metazoans, revealing that fewer errors in protein can extend health and life; The results of research on fruit flies can be extended to mammals, which may lead to treatments that improve the health of the elderly
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Cell Metabolism

DOI

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