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Microscopic imaging experiments developed by Olivier et al.
captured the escape
of fungi (Candida albicans) from immune cells (macrophages).
Left: Fungi inside immune cells (red
).
Right: Fugitive hyphae (blue) and nuclei of dead immune cells (green
).
Fungal pathogens have significant global implications for human health – they are often difficult to diagnose and treat, making there an urgent need for better diagnosis and more effective antifungal treatment
.
The paper, published in Cell Reports, led by Professor Ana Traven and doctoral student Françios Olivier, describes how Candida albicans uses sword-like filaments to contact toxin molecules and disrupt immune cell membranes in the cell death pathway, allowing it to escape and spread
.
This imaging technology, developed by Olivier in collaboration with Monash Microimaging, can pinpoint escaped fungi
in real time.
Candida is a yeast that often lives in the digestive tract and oral tract of humans, as well as urinary and reproductive organs
.
Professor Traven said targeting fugitive fungi "offers a promising therapeutic pathway that both prevents the spread of infection and has the potential to inhibit inflammation"
.
The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways
