Alcohol-dependent patients with cirrhosis use baclofen alcohol is safe and effective

Italy's Addorato and other reports, alcohol-dependent patients with cirrhosis treatment, can effectively increase the success rate of alcohol withdrawal, and patients can tolerate baclofen, no liver toxic side effects occur(Lancet 2007,370 (9603): 1915alcohol withdrawal is the most effective treatment for alcohol-dependent cirrhosis, but the use of related drug interventions may increase liver diseaseThe study was a double-blind randomized controlled studyBetween October 2003 and November 2006, 148 patients with cirrhosis dependent on alcohol were referred to the Institute of Internal Medicine in Rome, of which 84 patients were treated with papyrefen (42 cases in the group) or placebo (placebo group, 42 cases) for 12 weeksThe main return indicator is the proportion of patients who obtain and maintain alcohol withdrawal, and the specific indicator is the duration of total alcohol withdrawal and cumulative alcohol withdrawalEvaluate the efficacy and safety of baclofen in patients with cirrhosis to obtain and maintain alcohol withdrawalThe results showed that 30 patients in the baccarat group received and retained alcohol withdrawal, and 12 (29%) patients in the placebo group obtained and retained alcohol withdrawal (P-0.0001)There was no significant difference in the number of discontinued patients in the baclofen group and the placebo group (P.12)The cumulative alcohol withdrawal duration in the baclofen group was about 2 times that of the placebo group ( on average ( 62.8 to 5.4) days (30.8 to 5.5) days, p -0.001No liver side effects were foundThe researchers believe that the effectiveness of baclofen in the treatment of alcohol-dependent cirrhosis is significant, but longer treatment times and larger clinical studies are needed to optimize optimal treatment duration and to assess patient stotolerance problems that extend with treatment duration