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Innovation: The research group of Professor Jin Yan/Li Bei of the Third Affiliated Hospital of Air Force Military Medical University and the research group of Professor Chen Xin of Xi’an Jiaotong University have discovered a new mechanism of mitochondrial dysfunction in mesenchymal stem cells (MSCs) in the inflammatory microenvironment.
This mechanism designs functionalized silica nanoparticles to inhibit the formation of undesirable mitochondria in MSCs and promote the removal of damaged mitochondria through mitochondrial autophagy, restore mitochondrial function in MSCs, and treat inflammatory bone diseases
.
Keywords: Chronic inflammation; Mitochondria; Mesenchymal stem cells; Functionalized nanoparticles Chronic inflammation is widespread in various bone-related diseases, including periodontitis, arthritis and osteoporosis
.
Long-term chronic inflammatory stimulation will cause abnormal proliferation, migration and differentiation of tissue mesenchymal stem cells (MSCs), resulting in damaged bone tissue that cannot be regenerated after conventional treatment
.
Mitochondria are the main organelles in eukaryotic cells.
They are mainly responsible for producing the energy needed in the cell and are also the hub of multiple signal transduction
.
The mitochondria in cells are constantly changing dynamically, and can interact with the endoplasmic reticulum for ion exchange and signal transduction, such as Ca2+ and ROS signal transduction
.
At the same time, bad mitochondria can be eliminated through mitochondrial autophagy to maintain the balance of mitochondrial function
.
In recent years, many studies have shown that there are differences in the abundance, morphology and function of mitochondria in different cell types in different environments.
Abnormal mitochondrial function may lead to impaired MSCs regeneration
.
However, because its specific mechanism is not yet clear, there is currently a lack of effective methods to cure chronic inflammatory bone diseases by restoring MSCs mitochondrial function
.
Recently, the research group of Professor Jin Yan/Li Bei of the Third Affiliated Hospital of the Air Force Military Medical University and the research group of Professor Chen Xin of Xi’an Jiaotong University have cooperated.
Li Bei, Jin Yan, Jin Franc and Chen Xin jointly communicated in Advanced Science Magazine (IF=16.
869) Published a paper entitled "Nano-repairers rescue inflammation-induced mitochondrial dysfunction in mesenchymal stem cells", elucidating the new mechanism of mitochondrial dysfunction in mesenchymal stem cells (MSCs) in the inflammatory microenvironment
.
At the same time, functionalized silica nanoparticles are designed based on this mechanism to inhibit the formation of undesirable mitochondria in MSCs, and at the same time promote the clearance of damaged mitochondria through mitochondrial autophagy, thereby restoring mitochondrial function in MSCs and treating inflammatory bone diseases
.
(DOI: 10.
1002/advs.
202103839)
.
Researchers have found that chronic inflammation causes excessive Ca2+ in MSCs to transfer to mitochondria, resulting in abnormal mitochondrial structure and function
.
In addition, in the inflammatory microenvironment, the activation of the Wnt/β-catenin pathway inhibits mitochondrial autophagy, so that damaged mitochondria accumulate in MSCs, which further leads to MSCs dysfunction
.
Based on the above mechanism, we prepared nanoparticles that respond to the intracellular microenvironment (esterase and low pH), so that the nanoparticles METP/siβ-catenin can capture Ca2+ near the mitochondria after entering MSCs to regulate mitochondrial calcium flux, and In MSCs, siRNA is delivered to inhibit the Wnt/β-catenin pathway, activate mitochondrial autophagy, and clear abnormal mitochondria, thereby reversing mitochondrial dysfunction
.
This precisely designed functionalized nanoparticle can restore the function of mitochondria in MSCs and promote the regeneration of periodontal tissue and articular cartilage, thereby treating periodontitis and osteoarthritis, and further providing targeted therapy for other mitochondrial-related diseases New ideas
.
In this research, Associate Professor Li Bei, Professor Jin Yan, Professor Jin Franc, and Professor Chen Xin are the co-corresponding authors of the paper, and PhD candidates Zhai Qiming, Fei Dongdong, and Xi’an Jiaotong University graduate student Guo Xiaoyan are the co-authors of the paper.
One author
.
The above research work was supported by the National Key Research and Development Program (2017YFA0104800) and the National Natural Science Foundation of China (81991504, 81870768, 81930025, 81601606)
.
WILEY paper information: Nano-repairers rescue inflammation-induced mitochondrial dysfunction in mesenchymal stem cellsQiming Zhai, Xin Chen*, Dongdong Fei, Xiaoyan Guo, Xiaoning He, Wanmin Zhao, Songtao Shi, John Justin Gooding, Fang Jin*, Yan Jin*, Bei Li*Advanced ScienceDOI: 10.
1002/advs.
202103839 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley's high-quality open source journal founded in 2014, publishes innovative achievements and cutting-edge progress in materials science, physical chemistry, biomedicine, engineering and other fields
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
This mechanism designs functionalized silica nanoparticles to inhibit the formation of undesirable mitochondria in MSCs and promote the removal of damaged mitochondria through mitochondrial autophagy, restore mitochondrial function in MSCs, and treat inflammatory bone diseases
.
Keywords: Chronic inflammation; Mitochondria; Mesenchymal stem cells; Functionalized nanoparticles Chronic inflammation is widespread in various bone-related diseases, including periodontitis, arthritis and osteoporosis
.
Long-term chronic inflammatory stimulation will cause abnormal proliferation, migration and differentiation of tissue mesenchymal stem cells (MSCs), resulting in damaged bone tissue that cannot be regenerated after conventional treatment
.
Mitochondria are the main organelles in eukaryotic cells.
They are mainly responsible for producing the energy needed in the cell and are also the hub of multiple signal transduction
.
The mitochondria in cells are constantly changing dynamically, and can interact with the endoplasmic reticulum for ion exchange and signal transduction, such as Ca2+ and ROS signal transduction
.
At the same time, bad mitochondria can be eliminated through mitochondrial autophagy to maintain the balance of mitochondrial function
.
In recent years, many studies have shown that there are differences in the abundance, morphology and function of mitochondria in different cell types in different environments.
Abnormal mitochondrial function may lead to impaired MSCs regeneration
.
However, because its specific mechanism is not yet clear, there is currently a lack of effective methods to cure chronic inflammatory bone diseases by restoring MSCs mitochondrial function
.
Recently, the research group of Professor Jin Yan/Li Bei of the Third Affiliated Hospital of the Air Force Military Medical University and the research group of Professor Chen Xin of Xi’an Jiaotong University have cooperated.
Li Bei, Jin Yan, Jin Franc and Chen Xin jointly communicated in Advanced Science Magazine (IF=16.
869) Published a paper entitled "Nano-repairers rescue inflammation-induced mitochondrial dysfunction in mesenchymal stem cells", elucidating the new mechanism of mitochondrial dysfunction in mesenchymal stem cells (MSCs) in the inflammatory microenvironment
.
At the same time, functionalized silica nanoparticles are designed based on this mechanism to inhibit the formation of undesirable mitochondria in MSCs, and at the same time promote the clearance of damaged mitochondria through mitochondrial autophagy, thereby restoring mitochondrial function in MSCs and treating inflammatory bone diseases
.
(DOI: 10.
1002/advs.
202103839)
.
Researchers have found that chronic inflammation causes excessive Ca2+ in MSCs to transfer to mitochondria, resulting in abnormal mitochondrial structure and function
.
In addition, in the inflammatory microenvironment, the activation of the Wnt/β-catenin pathway inhibits mitochondrial autophagy, so that damaged mitochondria accumulate in MSCs, which further leads to MSCs dysfunction
.
Based on the above mechanism, we prepared nanoparticles that respond to the intracellular microenvironment (esterase and low pH), so that the nanoparticles METP/siβ-catenin can capture Ca2+ near the mitochondria after entering MSCs to regulate mitochondrial calcium flux, and In MSCs, siRNA is delivered to inhibit the Wnt/β-catenin pathway, activate mitochondrial autophagy, and clear abnormal mitochondria, thereby reversing mitochondrial dysfunction
.
This precisely designed functionalized nanoparticle can restore the function of mitochondria in MSCs and promote the regeneration of periodontal tissue and articular cartilage, thereby treating periodontitis and osteoarthritis, and further providing targeted therapy for other mitochondrial-related diseases New ideas
.
In this research, Associate Professor Li Bei, Professor Jin Yan, Professor Jin Franc, and Professor Chen Xin are the co-corresponding authors of the paper, and PhD candidates Zhai Qiming, Fei Dongdong, and Xi’an Jiaotong University graduate student Guo Xiaoyan are the co-authors of the paper.
One author
.
The above research work was supported by the National Key Research and Development Program (2017YFA0104800) and the National Natural Science Foundation of China (81991504, 81870768, 81930025, 81601606)
.
WILEY paper information: Nano-repairers rescue inflammation-induced mitochondrial dysfunction in mesenchymal stem cellsQiming Zhai, Xin Chen*, Dongdong Fei, Xiaoyan Guo, Xiaoning He, Wanmin Zhao, Songtao Shi, John Justin Gooding, Fang Jin*, Yan Jin*, Bei Li*Advanced ScienceDOI: 10.
1002/advs.
202103839 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley's high-quality open source journal founded in 2014, publishes innovative achievements and cutting-edge progress in materials science, physical chemistry, biomedicine, engineering and other fields
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
