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Aging: Only a slight decrease in memory?

 Last Update: 2021-11-01
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Mild cognitive impairment (MCI) is a state between normal aging and early dementia
.

People with MCI have an increased risk of dementia, which can be roughly divided into two subtypes, with different clinical trajectories:-Cases of non-amnestic MCI (aMCI) usually develop into Alzheimer's disease (AD), and Most cases of non-amnestic MCI (non-aMCI) develop into non-AD dementia

Mild cognitive impairment (MCI) is a state between normal aging and early dementia

Diagnosing clinicians often disagree on the diagnosis of MCI, and the Cronbach alpha value of MCI diagnosis is often only slightly higher than 0.

A previous meta-analysis that studied the continuity of AD concluded that AD had a significant decrease in peripheral brain-derived neurotrophic factor (BDNF)

In order to solve this heterogeneity problem, experts from the Department of Psychology, Yong Loo Lin School of Medicine, National University of Singapore, compared the healthy control group (n=56, 45 women) and the MCI group (n=40, 28 women).
To determine whether plasma BDNF, hs-CRP and DHEA-S can distinguish healthy individuals from MCI individuals
.

Researched the association between BDNF and other biomarkers and neurocognitive tests

The results showed that compared with healthy controls, BDNF was significantly higher in all causes of MCI, aMCI and non-aMCI
.

In addition, BDNF has good (AUC=0.

Compared with the control group, the logarithmic plasma BDNF levels of MCI cases caused by all causes

BDNF was significantly positively correlated with plasma hs-CRP (β=0.
26, 95%CI=0.
02-0.
50, p=0.
038), although the association weakened after controlling for BMI (β=0.
15, 95%CI=-0.
08~0.
38, p= 0.
186)
.

Various inverse associations between BDNF and detailed neurocognitive testing were also detected

BDNF was significantly positively correlated with plasma hs-CRP (β=0.

These findings indicate that the increase in BDNF is a compensation mechanism for preclinical dementia, supporting the neurotrophic and partial inflammation hypotheses of cognitive impairment

references:

Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study.

Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study.
https://doi.
org/10.
18632/aging.
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