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We all age gradual.
We all age gradual.
The tiny fruit fly has helped researchers to understand many big questions many times in history, such as the laws of genetics, the mechanism of embryonic development, the mechanism of innate immunity and the biological circadian rhyt.
Therefore, the researchers first detected the changes in the level of MAPK signaling triggered by learning in the brains of Drosophila of different ages, and found that the MAPK signaling can be normally activated and maintained for more than 15 minutes after learning in young Drosophila flies, and this activation occurs with agi.
Subsequently, the researchers used in vivo calcium imaging and pharmacology and other experimental methods to find that the vulnerability of short-term memory in aging Drosophila can be observed in real time through changes in calcium signals in the dendritic regions of a pair of memory output neuro.
FigureSchematic diagram of the biological mechanism of memory susceptible to interference after aging in Drosophila
FigureSchematic diagram of the biological mechanism of memory susceptible to interference after aging in DrosophilaNotably, aging-induced defects in MAPK signaling activation are also found in mice, rats, macaques, and humans themselves, and are thought to be associated with aging-induced memory impairment
Notably, aging-induced defects in MAPK signaling activation are also found in mice, rats, macaques, and humans themselves, and are thought to be associated with aging-induced memory impairment
This part of the research work was published online in the journal Aging Cell on May 15, 2022, with the title "Age-related memory vulnerability gradually lost in Drosophila MAPK-dependent protective mechanism leads to memory vulnerability after aging" (Age-related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK-dependent protection in Drosophila) , revealing a biological mechanism by which memory is more susceptible to disturbance after agi.
The corresponding author of the paper is Assistant Researcher Li Qian (Professor Zhong Yi's research group) at the School of Life Sciences, Tsinghua Universi.
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