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Aging Cell: How do aging immune cells change in the elderly?

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Cellular senescence is a stable state of proliferation that mammalian cells enter when responding to various signals and stresses.

immunity

In mouse models, this accumulation of age-related SCs has a great negative impact on physical fitness and health, because it promotes the development of aging and age-related diseases.

Aging leads to the gradual decline of immune system function, making the elderly more and more vulnerable to diseases and infections .

infection

Recently, researchers used the second-generation β-galactosidase fluorescent substrate and multi-parameter flow cytometry to prove that peripheral blood mononuclear cells (PBMCs) isolated from healthy people as the donor ages Shows a high degree of aging-related β-galactosidase (SA-βGal) activity.

As the donor ages, peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals show a high degree of aging-related β-galactosidase (SA-βGal) activity.

The percentage of senescent T lymphocytes in the elderly increases

Among them, the largest age-related growth was observed in the CD8+T cell population.

Among donors in their 60s, the proportion of cells with high SA-βGal activity reached an average of 64%.

Original source:

Ricardo I.

et al.

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