Aging cell: can conventional nutrition supplement resist Alzheimer's disease?

September 27, 2019 / BIOON / -- in a new study, researchers from biosign found that conventional tonic "choline" has the potential to prevent Alzheimer's disease (AD) Choline is a safe and easy to manage nutrient, which is naturally present in some foods and can be used as a dietary supplement In response, Ramon Velazquez, lead author of the ASU banner neurodegenerative disease research center (NDRC), and his colleagues studied whether this nutrition can reduce the incidence of Alzheimer's disease In a previous study, Velazquez and colleagues found that AD symptoms were relieved in offspring after choline supplementation in pregnant mice The latest study explored the effect of choline on adult mice The results showed that compared with the control mice, the spatial memory ability of the mice was improved when there was a high level of choline in the diet for a long time Interestingly, long-term intake of choline supplements reduced the activation of microglia Microglia are specialized cells that can remove harmful debris from the brain Although they occur naturally to keep the brain healthy, if they are over activated, brain inflammation and neuronal death (common symptoms of AD) will occur (picture source: www Pixabay Com) the microglial cell decrease in various neurodegenerative diseases related to diseases has provided new ideas for research, and proposed methods for treatment of various diseases, including brain injury, multiple sclerosis and Parkinson's disease The findings were published in the recent journal aging cell Choline protects the brain from Alzheimer's disease in at least two ways First, choline prevents amyloid beta plaques β - amyloid plaque is a marker pathology observed in Alzheimer's disease Secondly, choline supplementation can reduce the activation of microglia. In terms of mechanism, the decrease of microglia activation is driven by the change of two key receptors, namely α 7-nicotinic acetylcholine and sigma-1 receptor The results show that choline can be used as an agonist of sigma-1 receptor These results confirm that lifelong choline supplementation can change the expression of sigma-1 receptor, thus weakening the activation of microglia It is well known that Alzheimer's disease does harm to the brain long before clinical symptoms become apparent Once these symptoms are detected it is too late and the disease has become irreversible In addition to disorientation and memory loss, the disease also leads to loss of motor control In order to develop more effective treatment, we need to understand the disease itself, which is one of the highest requirements of modern medicine This study suggests that long-term supplementation of choline in the diet may reduce the impact of the disease Source of information: common numeric supplement may hold the answers to combining Alzheimer's disease source: Ramon Velazquez et al, lifeling choice supplement ameliorates Alzheimer's disease pathway and associated coherent defects by attaching microglia activation, aging cell (2019) Doi: 10.1111/acel.13037