 Home > Active Ingredient News > Study of Nervous System > Aging: Analysis of gut microbiota in Alzheimer's patients

Aging: Analysis of gut microbiota in Alzheimer's patients

 Last Update: 2022-02-19
 Source: Internet
 Author: User

Tags

automated data collection

sampling effect

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Previous studies have shown that amyloid beta (Aβ) deposition in the brain is an early neurological change in Alzheimer's disease (AD) patients
.

However, the pathogenesis of AD is not well explained

Recent evidence suggests a potential role for the gut microbiota (GM) in the development or exacerbation of AD

There is increasing evidence that the gut and central nervous system (CNS) interact through the following neurochemical pathways

Data were sourced from the PubMed, MEDLINE, Scopus and Cochrane Libraries from January 2000 to August 2021, including pre-intervention data from observational trials and intervention trials investigating the abundance of GM in AD-lineage patients and HCs
.

Effect size calculations were performed by random effects, inverse variance weighted models

Eleven studies consisting of 378 HC and 427 AD spectrum patients were included in the meta-analysis
.

AD patients showed a marked reduction in GM diversity compared with HC, whereas MCI did not

Shannon's index for comparisons between healthy controls (HC) and Alzheimer's disease (AD) pedigrees

In the HC and AD lineages, the abundance profiles of Alistipes and Bacteroides were affected differently by country
.

Finally, when the clinical stage was considered as a moderating factor, a comparison of Clostridium and Fareobacteriaceae abundances showed a larger effect size, with a gradient from MCI to AD stage

When clinical stage was considered as a moderating factor, a comparison of Clostridium and Fareobacteriaceae abundances showed a larger effect size, with a gradient from MCI to AD stages

CONCLUSIONS: Patients with AD spectrum showed altered GM abundance, which was mediated differently in different countries and clinical stages

references:

Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis.

Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis.
Leave a comment here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.