Age-related injuries were reversed in mouse models.

Weakness and decreased immunity are two of the main physical characteristics of older people.
, in a recent study published in Nature Metabolism, a team at the University of Bern and the University Hospital of Bern in Switzerland demonstrated in animal models that the use of a new cell therapy could stop or even partially reverse both age-related injuries.
's immune system function continues to decline with age, making them more susceptible to infectious diseases.
this is particularly true during seasonal influenza outbreaks or other viral diseases, such as neo-crown pneumonia.
because the effectiveness of vaccines is significantly reduced in older persons, older persons are particularly vulnerable to infectious pathogens and often exhibit higher mortality rates.
age-related decline in immunity, older people are often affected by physical weakness, which can have a negative impact on quality of life.
even as average life expectancy in humans continues to rise, longer life expectancy brings age-related health problems.
role of belly fat in the aging process, the team has begun looking for new ways to improve the health of the fast-growing elderly population.
years, scientists have speculated that chronic low inflammation accelerates the aging process and the development of age-related diseases.
previous studies have shown that visceral adipose tissue, known as belly fat, is essential for the development of chronic low inflammation.
immune cells in belly fat play a key role in regulating chronic low inflammation and aging-related processes, the researchers report.
their research proves that these immune cells can be used to reverse this process.
belly fat is a source of chronic inflammation, and the team confirmed that an immune cell eosinophil that is mainly present in the blood circulation is also present in abdominal fat in humans and mice.
although it has traditionally been thought that eosinophils can prevent parasitic infections and allergic respiratory diseases, eosinophils located in abdominal fat are responsible for maintaining local immune stability.
as we age, the frequency of eosinophils in abdominal fat decreases, while the number of inflammatory macrophages increases.
this immune cell imbalance, abdominal fat becomes a systematic source of inflammatory media in old age.
that eosinophil therapy promotes youth, the researchers looked at the possibility of reversing age-related damage by restoring the stability of immune cells in visceral adipose tissue. Dr Alexander Eggel, co-author of the study, said:
In different experimental methods, we have shown that local and systemic low inflammation is reduced by transplanting acidic granulocytes from young mice into aging mice.
these experiments, we observed acidic granulocytes selectively entering adipose tissue," the researchers added.
this method has a re-active effect on the aging body.
, the physical fitness of older animals improved significantly through endurance and grip tests.
addition, the therapy has a restoring effect on the immune system, as shown by improved immune response in older mice.
, co-author of the study, said: "Our results suggest that the biological processes and associated functional impairments of aging are more malleable than we previously thought.
importantly, age-related changes in the distribution of fat immune cells in mice were also confirmed in humans.
Eggel said: "Our future research is to use existing knowledge to build targeted treatments to promote and sustain healthy ageing in humans" ()