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About 80% of older adults report persistent pain
Nearly 50 percent of community-dwelling seniors reported similar complaints
A variety of adverse effects have been reported with opioid use in older adults
The study population included 2222 people aged 65-69 at baseline from the Australian Personality and General Health Study
Total MED with cumulative opioid exposure exceeding 2940 was significantly associated with worse Mini-Mental State Examination (MMSE) performance
People whose opioid exposure resulted in a cumulative total MED of more than 2940 had significantly lower scores on the MMSE compared to those who did not use opioids (Model 1: β=-0.
It was further shown that APOE was significantly associated with the performance of immediate and delayed recall
Taken together, chronic opioid use in older adults affects cognitive function, further encouraging the need for alternative pain management strategies in this population
Taken together, chronic opioid use in older adults affects cognitive function, further encouraging the need for alternative pain management strategies in this population
The effect of opioids on the cognitive function of older adults: results from the Personality and Total Health through life study , Age and Ageing, Volume 50, Issue 5, September 2021, Pages 1699–1708, https://doi.
The effect of opioids on the cognitive function of older adults: results from the Personality and Total Health through life
study