Against tradition, a small amount of pressure is good for cell health and longevity
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Last Update: 2017-12-18
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Source: Internet
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Author: User
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The human body is composed of countless cells What kind of cells are related to the health and longevity of the body? Richard I Morimoto, a molecular biologist at Northwestern University, found that low stress can keep cells healthy The findings will help scientists gradually solve the mystery of aging and degenerative diseases "Our ultimate goal is not to try to make people live longer, but to increase their health at the cellular and molecular levels, so that they can live a healthy life," Morimoto said In the genetic study of Caenorhabditis elegans, scientists found that the signal from the slightly compressed mitochondria could prevent the failure of the cytoplasmic protein folding quality monitoring system with age In turn, the accumulation of wrong proteins is quite common in degenerative diseases (such as Alzheimer's disease, Parkinson's disease, etc.) "For a long time, it has been thought that the pressure of mitochondria is not good for a long time But our findings overturn the tradition When you put a little pressure on the mitochondria, the pressure signals released by the mitochondria are actually the survival strategies of cells and animals They can make the animals more resistant to pressure, and their life span is extended like magic " In the study of biological aging, scientists have found that many of the identified components are conservative in all animals, so C elegans is an ideal model for the study of aging and aging related human diseases In 2015, Morimoto and Johnathan labbadia, a postdoctoral researcher in the laboratory, reported that the inhibition signal of germ cells to other tissues prevented the induction of protective cell stress response, and the molecular decline leading to cell aging started from reproductive maturity For nematodes with a life span of about 3 weeks, this process occurs 8-12 hours after maturity It is known that the molecular health of adult nematodes will fail within one to two days Researchers focused on two-day-old nematodes to find genes and ways to prevent molecular decline They screened about 22000 genes, one of which is called mitochondrial electron transport chain (etc), which seems to play an important role in regulating aging Researchers found that slightly down regulating etc activity, using small doses of exogenous chemicals, and pathogen exposure can lead to healthier animals "It never occurred to us that low-dose stress signals reset the living state of life," Morimoto said "We believe that some of these stress signals are interpreted by life as a signal that can reset itself and live longer The best mitochondria make cells and tissues stronger " This finding provides a new strategy for the study of human aging, which can prevent or stabilize the molecular decline of the elderly, improve the ability of cell self-regulation, and possibly prevent the early aging of tissues and organs.
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