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Evidence-based medicine, rational use of medicine
Acarbose is a biosynthetic pseudotetrasaccharide, which can delay the degradation of intestinal polysaccharides, oligosaccharides or disaccharides by inhibiting the activity of a-glucosidase on the brush edge of intestinal wall cells, slowing down the degradation and absorption of glucose from carbohydrates into the bloodstream, especially helping to control postprandial blood glucose
.
Therefore, it can be used clinically with dietary control for the treatment of type 2 diabetes, and can also reduce postprandial blood glucose in people with impaired glucose
tolerance.
But if used improperly, hypoglycemic drugs can also raise blood sugar!
How do you use acarbose?
Since the advantage of the drug is to lower blood sugar after meals, it is recommended to swallow the tablet whole immediately before meals or chew it with the first few bites
.
The general recommended dose is: the initial dose is 50mg once, 3 times a day, and then gradually increased to 0.
1g once, 3 times
a day.
In individual cases, it can be increased to 0.
2g once, 3 times a
day.
If the patient does not respond significantly after 4-8 weeks of taking the drug, the dose can be increased or combined with other hypoglycemic drugs
.
If the patient adheres to a strict diabetic diet and is still uncomfortable, the dose can not be increased, and sometimes the dose needs to be appropriately reduced, and the average dose is 0.
1 g at a time, 3 times
a day.
Hypoglycemic drugs also produce sugar? Need to pay attention to concomitant medication!
Although it is a hypoglycemic drug, it may cause blood sugar to rise
when combined with thiazide diuretics, corticosteroids, thyroid preparations, estrogen, etc.
For patients with multi-agent combined blood glucose control, combination with sulfonylurea hypoglycemic drugs and insulin may lead to hypoglycemia
.
In addition, when combined with cholestyramine, intestinal adsorbents, and digestive enzyme preparations, it may reduce drug absorption, thereby affecting the efficacy
.
Who can't use it?
In addition to allergic components, ketoacidosis, severe impaired liver and kidney function, chronic gastrointestinal disorders with obvious digestive and absorption disorders due to adverse reactions including flatulence, hyperperistalsis, etc.
, especially in patients with inflammatory bowel disease and diseases that may worsen due to flatulence (such as gastrocardioid syndrome, severe hernia, Patients with intestinal obstruction and intestinal ulcer) can not use the drug.
More popular drugs in Corey, where to learn?
Does Acarbose have to be taken with meals?
What should I do if I have low blood sugar after taking acarbose?
Which patients need dose adjustment?
References: [1] Acarbose tablets, drug insert, Sinopharm quasi-word H19990205
.
Click "Read Original" for more dry medications
