After drinking tea for thousands of years, is it anti-cancer or carcinogenic?

sirjasonwinters

sirjasonwinters

 

In addition to water, tea is one of the most popular beverages in the world.

In addition to water, tea is one of the most popular beverages in the world.

Due to the widespread dissemination of tea drinking culture, modern scientists have also begun to continuously study the mystery of tea to human health.

Recently, a new study by the University of California, Irvine, showed that the compounds in green tea and black tea can relax blood vessels by activating ion channel proteins in the blood vessel walls.

KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.

KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.

Catechins are the main polyphenols in green tea and have a variety of biological activities.

Catechins are the main polyphenols in green tea and have a variety of biological activities.

The study found that the two catechin flavonoid compounds in tea (epicatechin gallate ECG and epicatechin-3-gallate EGCG) respectively activated a special type of ion called KCNQ5 Channel protein allows potassium ions to diffuse out of cells to reduce cell excitability, dilate blood vessels, and thereby lower blood pressure.

Since as many as one-third of the adult population in the world suffers from high blood pressure, and this condition is considered to be the number one risk factor for cardiovascular disease and premature death globally, new methods for the treatment of high blood pressure have improved global Great potential for public health.

Since as many as one-third of the adult population in the world suffers from high blood pressure, and this condition is considered to be the number one risk factor for cardiovascular disease and premature death globally, new methods for the treatment of high blood pressure have improved global Great potential for public health.

In addition to its role in controlling blood vessel tension , KCNQ5 is also expressed in various parts of the brain, regulating the electrical activity and signal transmission between neurons.

Nowadays , many people like to drink milk tea, mixing black or green tea with milk.

In addition, the team also used mass spectrometry to find that heating green tea to 35 degrees Celsius would change its chemical composition, making it more effective to activate KCNQ5.

In addition, the team also used mass spectrometry to find that heating green tea to 35 degrees Celsius would change its chemical composition, making it more effective to activate KCNQ5.

The production and consumption of tea has a history of more than 4,000 years.

The production and consumption of tea has a history of more than 4,000 years.
At present, there are more than 2 billion cups of tea consumed in the world every day, second only to water in the consumption of people in the world.
The three common types of caffeine tea (green tea, oolong tea, and black tea) are all made from the leaves of the evergreen camellia, the difference being the degree of fermentation during the tea making process.

Today, after a long historical journey, tea has taken root in dozens of countries around the world, and has become a healthy drink in these countries and even the world, and countless people admire it.

Today, after a long historical journey, tea has taken root in dozens of countries around the world, and has become a healthy drink in these countries and even the world, and countless people admire it.

The country with the highest tea production in each country is China, followed by India, Kenya, and Sri Lanka.
In 2015, China's tea production accounted for half of the world's tea production.
According to data from the United Nations Food and Agriculture Organization, it is estimated that by 2023, the world's black tea production will grow at a rate of 2.
9% per year, reaching 4.
17 million tons.
By 2023, the world's green tea production is expected to grow at an annual rate of 8.
2%, reaching 2.
97 million tons.

The country with the highest tea production in each country is China, followed by India, Kenya, and Sri Lanka.
In 2015, China's tea production accounted for half of the world's tea production.
According to data from the United Nations Food and Agriculture Organization, it is estimated that by 2023, the world's black tea production will grow at a rate of 2.
9% per year, reaching 4.
17 million tons.
By 2023, the world's green tea production is expected to grow at an annual rate of 8.
2%, reaching 2.
97 million tons.
In 2015, China's tea production accounted for half of the world's tea production.
According to data from the United Nations Food and Agriculture Organization, it is estimated that by 2023, the world's black tea production will grow at a rate of 2.
9% per year, reaching 4.
17 million tons.
By 2023, the world's green tea production is expected to grow at an annual rate of 8.
2%, reaching 2.
97 million tons.
Black tea grows.
Source: U.
S.
Food and Agriculture Organization Green Tea Growth.
U.
S.
Food and Agriculture Organization

 

In addition, many studies have confirmed that the polyphenols contained in tea have anti-cancer effects.
In February 2021, a study published in Nature Communications showed that EGCG in green tea may enhance the anti-cancer activity of p53.
p53 is a natural anti-cancer gene, known as the "guardian of the genome" because of its ability to repair DNA damage or destroy cancer cells.

In addition, many studies have confirmed that the polyphenols contained in tea have anti-cancer effects.
In February 2021, a study published in Nature Communications showed that EGCG in Nature Communications green tea may enhance the anti-cancer activity of p53.
The EGCG in green tea may enhance the anti-cancer activity of p53.
p53 is a natural anti-cancer gene, known as the "guardian of the genome" because of its ability to repair DNA damage or destroy cancer cells.
Jing Zhao, Alan Blayney.
et al.
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
Nature Communications (2021).
DOI: 10.
1038/s41467-021-21258-5

 

P53 has several well-known anti-cancer functions, including stopping cell growth for DNA repair, activating DNA repair, and triggering programmed cell death (called apoptosis) if DNA damage cannot be repaired.
Mutations in p53 have been found in more than 50% of human cancers, and EGCG is the main antioxidant in green tea.
Now it has been discovered that there is a previously unknown and direct interaction between the two, which points to the development of anti-cancer drugs.
A new path.

P53 has several well-known anti-cancer functions, including stopping cell growth for DNA repair, activating DNA repair, and triggering programmed cell death (called apoptosis) if DNA damage cannot be repaired.
Mutations in p53 have been found in more than 50% of human cancers, and EGCG is the main antioxidant in green tea.
Now it has been discovered that there is a previously unknown and direct interaction between the two, which points to the development of anti-cancer drugs.
A new path.

Studies have found that EGCG disrupts the p53-MDM2 interaction and inhibits the ubiquitination of p53 mediated by MDM2.
Normally, after p53 is produced in the body, it will be rapidly degraded when the N-terminal domain interacts with the protein of MDM2.
This regular production and degradation cycle keeps the level of p53 at a low constant value.
However, both EGCG and MDM2 are in the same binding site of p53, which is the disordered N-terminal domain (NTD), and EGCG competes with MDM2.
When EGCG binds to p53, the protein is not degraded by MDM2, so after direct interaction with EGCG, the level of p53 will increase.

Studies have found that EGCG disrupts the p53-MDM2 interaction and inhibits the ubiquitination of p53 mediated by MDM2.
Normally, after p53 is produced in the body, it will be rapidly degraded when the N-terminal domain interacts with the protein of MDM2.
This regular production and degradation cycle keeps the level of p53 at a low constant value.
However, both EGCG and MDM2 are in the same binding site of p53, which is the disordered N-terminal domain (NTD), and EGCG competes with MDM2.
When EGCG binds to p53, the protein is not degraded by MDM2, so after direct interaction with EGCG, the level of p53 will increase.
EGCG disrupts the p53-MDM2 interaction by binding to the N-terminus of p53

 

In addition, the interaction between EGCG and p53–NTD is highly dynamic, involving multiple binding interfaces.
As we all know, NTD is the target of anti-cancer drug discovery.
A small molecule EGCG with a MW value of 458 Da can effectively disrupt the interaction between p53 and MDM2 and has a dynamic interface.
In the past, drug discovery aimed at destroying p53-MDM2 mainly focused on the NTD binding pocket on the surface of MDM2.
This data indicates that the NTD of p53 may also be a good target for the discovery of small-molecule cancer drugs.

In addition, the interaction between EGCG and p53–NTD is highly dynamic, involving multiple binding interfaces.
As we all know, NTD is the target of anti-cancer drug discovery.
A small molecule EGCG with a MW value of 458 Da can effectively disrupt the interaction between p53 and MDM2 and has a dynamic interface.
In the past, drug discovery aimed at destroying p53-MDM2 mainly focused on the NTD binding pocket on the surface of MDM2.
This data indicates that the NTD of p53 may also be a good target for the discovery of small-molecule cancer drugs.

The results of this study explain how EGCG can enhance the anti-cancer activity of p53 and open the door to the development of drugs similar to EGCG compounds.

The results of this study explain how EGCG can enhance the anti-cancer activity of p53 and open the door to the development of drugs similar to EGCG compounds.
The results of this study explain how EGCG can enhance the anti-cancer activity of p53 and open the door to the development of drugs similar to EGCG compounds.
img.
mp.
itc

 

There are still some controversies as to whether tea drinking can fight cancer.
In August 2019, Professor Li Liming’s team published in the European Journal of Epidemiology entitled "The Association of Tea Drinking and Cancer Risk: A Prospective Cohort Study of 500,000 Chinese Adults" The paper used data from more than 500,000 Chinese to analyze the relationship between the habit of drinking tea and the risk of various cancers.

There are still some controversies about whether tea drinking can fight cancer.
In August 2019, Professor Li Liming’s team published in the European Journal of Epidemiology entitled "The Association of Tea Drinking and Cancer Risk: A Prospective Cohort Study of 500,000 Chinese Adults" The paper used data from more than 500,000 Chinese to analyze the relationship between the habit of drinking tea and the risk of various cancers.
Analyzed the relationship between the habit of drinking tea and the risk of various cancers.

Based on the long-term follow-up of more than 450,000 people, the study examined whether tea drinking is related to the incidence of all cancers and six major cancers-lung cancer, stomach cancer , colorectal cancer , liver cancer, and female breast and cervical cancer.

Based on the long-term follow-up of more than 450,000 people, the study examined whether tea drinking is related to the incidence of all cancers and six major cancers-lung cancer, stomach cancer , colorectal cancer , liver cancer, and female breast and cervical cancer.
Stomach cancer colorectal cancer breast cancer

During an average follow-up of 10.
1 years, 22652 cases of cancer occurred, including 4,046 (17.
9%) lung cancer, 2366 (10.
4%) gastric cancer, 2267 (10.
0%) colorectal cancer, 1874 (8.
3%) liver cancer, There were 1984 cases (8.
8%) of women with breast cancer and 868 cases (3.
8%) with cervical cancer.

During an average follow-up of 10.
1 years, 22652 cases of cancer occurred, including 4,046 (17.
9%) lung cancer, 2366 (10.
4%) gastric cancer, 2267 (10.
0%) colorectal cancer, 1874 (8.
3%) liver cancer, There were 1984 cases (8.
8%) of women with breast cancer and 868 cases (3.
8%) with cervical cancer.

Preliminary analysis results show that compared with people who drink tea less than once a week, people who consume more than 4g of tea per day have a 26% increase in overall cancer risk, a 62% increase in lung cancer risk, and a 29% increase in gastric cancer risk.

Preliminary analysis results show that compared with people who drink tea less than once a week, people who consume more than 4g of tea per day have a 26% increase in overall cancer risk, a 62% increase in lung cancer risk, and a 29% increase in gastric cancer risk.
Compared with people who drink tea less than once a week, people who consume more than 4g of tea per day have a 26% increase in overall cancer risk, a 62% increase in lung cancer risk, and a 29% increase in gastric cancer risk.
Disaggregate all cancer risks and HR (95% CI) of smoking (a) and drinking (b) according to the frequency of tea drinking.
Li X, Yu C, Guo Y.
et al.
Association between tea consumption and risk of cancer: a prospective cohort study of 0.
5 million Chinese adults.
Eur J Epidemiol.
2019 Aug;34(8):753-763.

 

Researchers found that in this study, people who drank more tea tended to smoke and drink more.
They thought that tea could prevent cancer, so they let go of smoking and drinking, but in the end cancer came to their door.
Tea contains caffeine, which can stimulate the gastric mucosa.
This content is nothing in weak tea, but if you love to drink strong tea and drink it for a long time, it may increase the incidence of gastric cancer.
Chinese people like to drink hot tea, but hot water above 65℃ will scald the esophagus, and repeated scalds may induce esophageal cancer.

Researchers found that in this study, people who drank more tea tended to smoke and drink more.
They thought that tea could prevent cancer, so they let go of smoking and drinking, but in the end cancer came to their door.
Tea contains caffeine, which can stimulate the gastric mucosa.
This content is nothing in weak tea, but if you love to drink strong tea and drink it for a long time, it may increase the incidence of gastric cancer.
Chinese people like to drink hot tea, but hot water above 65℃ will scald the esophagus, and repeated scalds may induce esophageal cancer.

Therefore, it may not be known whether tea is anti-cancer, but don’t use tea as an anti-cancer drug and let your bad habits go.

Therefore, it may not be known whether tea is anti-cancer, but don’t use tea as an anti-cancer medicine and let your bad habits go.
It may not be known whether tea is anti-cancer, but don’t use tea as an anti-cancer medicine and let your bad habits go.

China is the hometown of tea.
The medicinal effects of tea are deposited after a long historical process.
According to historical data, our ancestors discovered the practical effect of tea: detoxification in the Shennong era more than 5,000 years ago.
In our country's first drug monograph, "Shennong's Herbal Medicine", there is "Shennong's Taste of Herbs", which was solved in full after encountering seventy-two poisons every day.
"Tea can be used for medicinal purposes, chewed and taken orally, to clear away heat, and externally to reduce inflammation and detoxification.

China is the hometown of tea.
The medicinal effects of tea are deposited after a long historical process.
According to historical data, our ancestors discovered the practical effect of tea: detoxification in the Shennong era more than 5,000 years ago.
In our country's first drug monograph, "Shennong's Herbal Medicine", there is "Shennong's Taste of Herbs", which was solved in full after encountering seventy-two poisons every day.
"Tea can be used for medicinal purposes.
It can be taken orally by chewing, to clear away heat, and externally for anti-inflammatory and detoxification.
" "Tea can be used for medicinal purposes.

For the Chinese people, tea carries the imprint and understanding of civilization of the people on the land of the East China, forming a group of its own, continuously supplying indispensable national spiritual food for the Chinese nation, and is the sum of the material culture and spiritual culture of the Chinese civilization.
From ancient times to the present, from south to north, what kind of tea Chinese people love to drink, why do they drink it, what are the benefits of drinking tea, what etiquette should be paid to when drinking tea, and what insights and principles have been drunk.
.
.
Become the soul of the nation The indelible part.

For the Chinese people, tea carries the imprint and understanding of civilization of the people on the land of the East China, forming a group of its own, continuously supplying indispensable national spiritual food for the Chinese nation, and is the sum of the material culture and spiritual culture of the Chinese civilization.
From ancient times to the present, from south to north, what kind of tea Chinese people love to drink, why do they drink it, what are the benefits of drinking tea, what etiquette should be paid to when drinking tea, and what insights and principles have been drunk.
.
.
Become the soul of the nation The indelible part.

In today's era of great changes in which the new technological revolution has made mankind go ahead and the degree of human alienation is increasing, you may wish to relax and enjoy tea occasionally.

In today's era of great changes in which the new technological revolution has made mankind go ahead and the degree of human alienation is increasing, you may wish to relax and enjoy tea occasionally.
In today's era of great changes in which the new technological revolution has made mankind go ahead and the degree of human alienation is increasing, you may wish to relax and enjoy tea occasionally.
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