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Affiliated Renji Hospital team discovered the circadian rhythm mechanism of the high incidence of clinical thrombotic events in the morning

 Last Update: 2022-04-18
 Source: Internet
 Author: User

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On March 10, the Cardiology Department of Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine published a research paper in the internationally renowned journal "European Heart Journal".

Thrombotic events are a common hazard of chronic diseases such as cardiovascular disease and tumors

Researchers have found in clinical studies that human platelet aggregation and thrombosis have a morning peak phenomenon

Using a variety of preclinical thrombosis models, the researchers revealed that the circadian clock nuclear receptor Rev-erbα is a co-driving factor of platelet activation and thrombosis in thrombotic events, and that, as the mother cell of platelets in humans, the circadian clock in mature megakaryocytes in the bone marrow.

Renji Hospital’s Cardiology Department has a profound background.

author:

Affiliated Renji Hospital

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Affiliated Renji Hospital

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