Advances were made in the study of behavioral and olfactory neurodevelopment in male mice.

Reporter August 4 from Hebei University School of Life Sciences was informed that the professor Wang Zhenshan team in male mouse behavior and olfactory neurodevelopment research field has made progress.
research is published online in the European Organization for Molecular Biology Report.
it is understood that, as an important part of mammalian olfactory system, the main role of olfactory epiderm is to perceive external odor molecules, its olfactory nerve cells have the ability to regenerate for life.
the olfactory epiderm is in direct contact with the external environment, the epigenological genetic factors play an important regulatory role in the proliferation and differentiation of olfactory nerve cells in the changing environment, but its mechanism is still unclear.
In the study, Wang Zhenshan team obtained a variety of gene-knocking low mice by repeating the regular clustered intervals and their related proteins, oligopoly DNA interference, adeno-related virus packaging, etc., and systematically expounded the tiny de-epidermal tissues in adult mice. The olfactory function of ICN 200 was found to show that male mice showed attack and mating behavior defects after the expression of tiny DNA 200 decreased in olfactory eppidermal tissue, and the proliferation of spherical substrate stem cells was enhanced and the ability of olfactory neurons to differentiate was reduced.
In addition, the team further discovered that the tiny DNA 200 target ketone diacid and iron ion-dependent bioxygenase 3 gene, and ketone dioxydrate and iron ion-dependent hydrogenase 3 gene interact with the neurogenetic inhibitor gene to jointly regulate olfactory-mediated behavior and olfactory epidural tissue nerve differentiation process.
The study revealed the regulatory role of the micro-DNA 200-ketonic acid and iron ion-dependent bioxygenase 3 gene-neurogrowth inhibitor gene signaling axis in olfactory-mediated male mouse behavior and olfactory epidural neuron development.
the results of this study have improved the understanding of the molecular mechanism of olfactory, and also have some enlightenment to the treatment of olfactory-related diseases.
the research was funded by the National Natural Science Foundation of China, the Institute of Life Sciences and Green Development of Hebei University, and the Graduate School of Hebei University.
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