Recently, Pei Renjun, a researcher at the Suzhou Institute of Nanotechnology and Nano-Bionics, Chinese Academy of Sciences, led a research team to use the coordination of tannic acid (TA) with iron ions to prepare functionalized ferroferric oxide magnetic nanoparticles, and successfully obtained 8 kinds of magnetic nanoparticles.
(TA) ACS Applied Materials & Interfaces Previously, Pei Renjun’s team cooperated with the University of California research team to integrate the technological advantages of click chemistry, multiple antibody "cocktails", nanostructured substrates, and microfluidic "chaotic mixers" to establish a method based on tumor extracellular vesicles (EVs).
Nature Communications Speaking of these two achievements, Pei Renjun introduced that liquid biopsy, as an emerging tumor diagnosis technology, has attracted widespread attention due to its advantages of non-invasiveness, high sensitivity, and convenient operation
Existing studies have shown that these markers play an important role in tumor diagnosis, recurrence, metastasis, treatment effect evaluation, medication guidance and prognosis
In order to solve the above problems, Pei Renjun's research team reacted tannic acid (TA) solution with magnetic nanoparticles (MNPs) at room temperature to prepare functionalized magnetic nanoparticles, and established a broad-spectrum separation of heterogeneity from patient blood samples The CTCs method captures 1-10 CTCs from 1 ml of blood from 8 cancer patients
In addition, Pei Renjun’s research team cooperated with the University of California research team to use three hepatocellular carcinoma-specific antibodies as affinity molecules to achieve hepatocytes through the bio-orthogonal click reaction between tetrazine and trans-cyclooctene (TCO) The high-efficiency and high-purity separation of cancer-derived EVs, and then the use of droplet digital PCR (ddPCR) technology to verify the diagnosis of clinical plasma samples for the selected 10 gene combinations
Related paper information: https://doi.
https://doi.
org/10.
1021/acsami.
0c20916 https://doi.
org/10.
1021/acsami.
0c20916
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