Advances have been made in the study of neural mechanisms that encode similar male characteristics.

On September 21st Neuron published a research paper online entitled "Specific perception of the same species of male neurons associated with aggressive behavior."
the study was completed by the Center for Brain Science and Intelligent Technology Excellence and Innovation of the Chinese Academy of Sciences (Neuroscience Research Institute), the Shanghai Brain Science and Brain Research Center, and the Xu Xiaohong Research Group of the National Key Laboratory of Neuroscience.
The study used calcium signal recording, chemical genetic manipulation and electrophysiology of brain tablets to analyze the prekernels of the lower papules by integrating olfactory information, specifically encoding the male information of the same species, and then regulating the cellular and neural loop mechanisms of mouse attack behavior.
instincts of social behavior are essential for population reproduction.
before behavior can take place, animals need to integrate sensory information, determine the sex of individuals of the same species, and further exhibit appropriate behavior.
, for example, males perform courtship on females, while attacks on other males.
previous studies have found that when the olfactory organ, the plow nose, was destroyed, male mice lost their aggressive behavior and showed courtship on both male and female counterparts.
suggests that mice's gender judgment of the same species is largely dependent on olfactory information.
Although studies have shown that specific nuclear groups in the lower pasum brain drive attacks and courtship behaviors, it is not clear how these clusters integrate gender information from the olfactory system under physiological conditions and further guide the neural mechanisms of behavior.
Using a calcium signal recording system, Xu Xiaohong's team found that nerve cells (PMvDAT) that express dopamine transporters in the pre-nucleosome of the abdominal nipples responded strongly when the mice sniffed the urine of adult male mice, while the urine response was minimal in despotic males, female mice, young mice, and rats.
When pharmacogenetic methods were used to inhibit PMvDAT nerve cells, male mice lost their ability to recognize male urine, and correspondingly, attacks on male invaders decreased significantly.
, activating this group of PMvDAT cells increased attacks on male mice.
Further, the team used the Cation Channel (Trpc2) gene to knock out mice, disrupting the olfactory signaling of the plow's nose, and found that in male mice with the gene knockout, the response of PMvDAT cells to male mice's urine decreased significantly, indicating that PMvDAT cells integrated olfactory information from the plow nose.
using viral tracer, calcium signaling and pharmacological genetic methods, the team found and confirmed that urine signals from male mice with plow noses were transmitted to PMvDAT cells through the abdominal end-print bed nucleus.
studies have shown that PMvDAT cells specifically encode male-like information and further guide behavior.
This study analyzes the cellular and loop mechanisms that transmit information about male animals to the lower pasum and cause aggressive behavior, and lays the foundation for further study of the processing of gender-specific olfactory information, the regulation of sex-specific sexual behavior, and the neural basis of gender perception and consciousness.
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