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Abstract: The team of Professor Qin Ling from the Chinese University of Hong Kong, together with Professor Jufang He from City University of Hong Kong and Professor Jie Zhao from Shanghai Jiaotong University, found that decreased synthesis of calcitonin gene-related peptide (CGRP) in the dorsal root ganglia (DRG) of the lumbar spine is a delayed osteoporotic fracture An important reason for healing, an implantable electrode that supports minimally invasive surgery has been specially developed to increase the synthesis and release of DRG CGRP
.
A series of experiments confirmed that electrical stimulation with specific parameters can promote DRG to synthesize CGRP and stimulate the nerve endings that innervate the femur to release CGRP through the Ca2+/CaMKII/CREB signaling pathway, thereby increasing H-shaped blood vessels and significantly promoting femoral fracture healing
.
In recent years, more and more studies have found that CGRP-positive nerve fibers play an important role in bone regeneration
.
In the early stage of fracture, the ingrowth of CGRP-positive nerve fibers can be detected in the cartilage callus and periosteum
.
After the nerve endings are released, CGRP can directly act on bone marrow mesenchymal stem cells, periosteal stem cells, osteoblasts, etc.
, and exert a biological effect of promoting osteogenic differentiation
.
The research group of Professor Qin Ling found that the expression of DRG and CGRP in the callus of osteoporotic rats in the early stage of fracture was significantly lower than that of healthy animal models of the same age
.
Direct injection of CGRP at the fracture site can effectively accelerate fracture healing
.
It is true that the direct application of CGRP, a biological peptide, is subject to many limitations: (1) high storage requirements in vitro; (2) short half-life in vivo; (3) low bioavailability of the peptide
.
Therefore, the development of strategies to regulate the synthesis and targeted release of CGRP in the body can effectively promote bone regeneration
.
The authors of the study confirmed that CGRP synthesized in DRG will be transported along sensory nerve fiber axons to peripheral tissues and exert its biological functions
.
The biological activity of DRG is closely related to electrical signals, so electrical stimulation is a feasible means to regulate the function of DRG
.
By culturing DRG neurons in vitro, the research group screened specific electrical stimulation parameters that can promote DRG synthesis and release, and discovered that the main pathway for electrical stimulation to promote CGRP synthesis is the Ca2+/CaMKII/CREB signaling pathway
.
Based on this, the research team developed an implantable flexible microelectrode and successfully implanted it around the DRG of the rat's lumbar spine
.
Studies have found that 20 minutes of electrical impulse stimulation per day can significantly increase the number of neurons expressing CGRP in the DRG of the rat lumbar spine, increase the content of CGRP in the callus, and then promote the formation of H-type blood vessels, the growth of new bones, and accelerate osteoporosis.
Fracture healing
.
This study further confirms the important role of sensory nerves in fracture healing, and provides new ideas for the development of devices and clinical applications that promote bone regeneration based on remote control of sensory nerves
.
Related papers are published online in Advanced Science
.
Dr.
Mi Jie, Dr.
Xu Jiankun (Assistant Professor), and Doctoral Candidate Yao Zhi from the Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, are the co-first authors of the paper
.
Professor Qin Ling from the Chinese University of Hong Kong, Professor He Jufang from City University of Hong Kong, and Professor Zhao Jie from the Ninth People's Hospital of Shanghai Jiaotong University are the co-corresponding authors of the paper
.
Professor Qin Ling’s research group has long been concerned with basic research and clinical translational work of incurable bone diseases, focusing on basic and clinical translational medicine research of plant and mineral-derived orthopedic drugs and orthopedic internal plants, including plant-derived Chinese medicine small molecule compounds and biodegradable Magnesium-based intraosseous plants promote bone regeneration and other directions, establishing an efficient industry-university-research cooperation platform
.
As the chief scientist of major Hong Kong, national and international research projects, Professor Qin Ling has received a total of more than 100 million yuan in scientific research funds.
He has co-led the development of high-purity magnesium orthopedic screws for femoral head necrosis and 3D printed magnesium-containing porous scaffolds for bone replacement with domestic companies and partners.
Materials and related innovative products were successively certified by the National Innovative Medical Products in 2014 and 2018, and entered multi-center clinical trials in 2019
.
Nature magazine once reported on the related scientific research results and clinical translation work of Professor Qin Ling and his team (https://
.
As the corresponding author, Professor Qin Ling has published more than 360 papers in mainstream international journals such as Nature Medicine, Materials Today, Annals of the Rheumatic Diseases, Advanced Science, ACS Central Science, Biomaterials, etc.
, and has been cited more than 13,000 times with an H-index of 60
.
Professor Qin Ling has served in 10 international and domestic academic organizations, including the former chairman of the International Chinese Bone Research Society (2009-2011), Journal of Orthopaedic Translation (Editor-in-Chief), Journal of Bone and Mineral Research (Editorial Board) and International Journal of Sports Medicine (Editor), Journal of Orthopedics and Research (Associate Editor), Journal of Clinical Biomechanics (Associate Editor)
.
WILEY paper information: Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related PeptideJie Mi, Jian-Kun Xu, Zhi Yao, Hao Yao, Ye Li, Xuan He, Bing-Yang Dai, Li Zou, Wen- Xue Tong, Xiao-Tian Zhang, Pei-Jie Hu, Ye Chun Ruan, Ning Tang, Xia Guo, Jie Zhao*, Ju-Fang He*, Ling Qin* Advanced Science DOI: 10.
1002/advs.
202103005 Click on the lower left corner "to read the original "To view the original paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
.
A series of experiments confirmed that electrical stimulation with specific parameters can promote DRG to synthesize CGRP and stimulate the nerve endings that innervate the femur to release CGRP through the Ca2+/CaMKII/CREB signaling pathway, thereby increasing H-shaped blood vessels and significantly promoting femoral fracture healing
.
In recent years, more and more studies have found that CGRP-positive nerve fibers play an important role in bone regeneration
.
In the early stage of fracture, the ingrowth of CGRP-positive nerve fibers can be detected in the cartilage callus and periosteum
.
After the nerve endings are released, CGRP can directly act on bone marrow mesenchymal stem cells, periosteal stem cells, osteoblasts, etc.
, and exert a biological effect of promoting osteogenic differentiation
.
The research group of Professor Qin Ling found that the expression of DRG and CGRP in the callus of osteoporotic rats in the early stage of fracture was significantly lower than that of healthy animal models of the same age
.
Direct injection of CGRP at the fracture site can effectively accelerate fracture healing
.
It is true that the direct application of CGRP, a biological peptide, is subject to many limitations: (1) high storage requirements in vitro; (2) short half-life in vivo; (3) low bioavailability of the peptide
.
Therefore, the development of strategies to regulate the synthesis and targeted release of CGRP in the body can effectively promote bone regeneration
.
The authors of the study confirmed that CGRP synthesized in DRG will be transported along sensory nerve fiber axons to peripheral tissues and exert its biological functions
.
The biological activity of DRG is closely related to electrical signals, so electrical stimulation is a feasible means to regulate the function of DRG
.
By culturing DRG neurons in vitro, the research group screened specific electrical stimulation parameters that can promote DRG synthesis and release, and discovered that the main pathway for electrical stimulation to promote CGRP synthesis is the Ca2+/CaMKII/CREB signaling pathway
.
Based on this, the research team developed an implantable flexible microelectrode and successfully implanted it around the DRG of the rat's lumbar spine
.
Studies have found that 20 minutes of electrical impulse stimulation per day can significantly increase the number of neurons expressing CGRP in the DRG of the rat lumbar spine, increase the content of CGRP in the callus, and then promote the formation of H-type blood vessels, the growth of new bones, and accelerate osteoporosis.
Fracture healing
.
This study further confirms the important role of sensory nerves in fracture healing, and provides new ideas for the development of devices and clinical applications that promote bone regeneration based on remote control of sensory nerves
.
Related papers are published online in Advanced Science
.
Dr.
Mi Jie, Dr.
Xu Jiankun (Assistant Professor), and Doctoral Candidate Yao Zhi from the Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, are the co-first authors of the paper
.
Professor Qin Ling from the Chinese University of Hong Kong, Professor He Jufang from City University of Hong Kong, and Professor Zhao Jie from the Ninth People's Hospital of Shanghai Jiaotong University are the co-corresponding authors of the paper
.
Professor Qin Ling’s research group has long been concerned with basic research and clinical translational work of incurable bone diseases, focusing on basic and clinical translational medicine research of plant and mineral-derived orthopedic drugs and orthopedic internal plants, including plant-derived Chinese medicine small molecule compounds and biodegradable Magnesium-based intraosseous plants promote bone regeneration and other directions, establishing an efficient industry-university-research cooperation platform
.
As the chief scientist of major Hong Kong, national and international research projects, Professor Qin Ling has received a total of more than 100 million yuan in scientific research funds.
He has co-led the development of high-purity magnesium orthopedic screws for femoral head necrosis and 3D printed magnesium-containing porous scaffolds for bone replacement with domestic companies and partners.
Materials and related innovative products were successively certified by the National Innovative Medical Products in 2014 and 2018, and entered multi-center clinical trials in 2019
.
Nature magazine once reported on the related scientific research results and clinical translation work of Professor Qin Ling and his team (https://
.
As the corresponding author, Professor Qin Ling has published more than 360 papers in mainstream international journals such as Nature Medicine, Materials Today, Annals of the Rheumatic Diseases, Advanced Science, ACS Central Science, Biomaterials, etc.
, and has been cited more than 13,000 times with an H-index of 60
.
Professor Qin Ling has served in 10 international and domestic academic organizations, including the former chairman of the International Chinese Bone Research Society (2009-2011), Journal of Orthopaedic Translation (Editor-in-Chief), Journal of Bone and Mineral Research (Editorial Board) and International Journal of Sports Medicine (Editor), Journal of Orthopedics and Research (Associate Editor), Journal of Clinical Biomechanics (Associate Editor)
.
WILEY paper information: Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related PeptideJie Mi, Jian-Kun Xu, Zhi Yao, Hao Yao, Ye Li, Xuan He, Bing-Yang Dai, Li Zou, Wen- Xue Tong, Xiao-Tian Zhang, Pei-Jie Hu, Ye Chun Ruan, Ning Tang, Xia Guo, Jie Zhao*, Ju-Fang He*, Ling Qin* Advanced Science DOI: 10.
1002/advs.
202103005 Click on the lower left corner "to read the original "To view the original paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
