Acta Neuropathologica: Ultra-sensitive and specific ultra-sensitive RT-QuIC analysis for Louis-associated synaptic nucleoprotein disease.

Clinically synaptic nucleosis shows highly variable performance in response to treatment and speed of progressAs a result, the prognosis of these diseases is very variableLouis osmosis () is the most common synaptic nucleosis including and most patients who may clinically manifest as Parkinson's disease or cognitive impairment (or both) and two atypical Parkinson's disease (including overlapping symptoms of progressive nuclear palsy ()) and cortical degeneration () and neurodegenerative dementia are mainly Alzheimer's disease ()Clinical conditions such as isolated sleep behavior disorders () and purely isolated autonomic nerve failure () are also shown to be caused by synaptic nucleoprotein diseaseThe identification of biomarkers for synaptic nucleoprotein disease will be of great value in clinical practice for the identification and early diagnosis of prognosis assessment and monitoring of disease progressionMethods: A new method of in vitro amplification based on pathogen protein seeds was obtained by forcing natural monomers into their misfolded counterpartsA pathogenic sample derived from a patient or other biological fluid or tissue is cultured with its natural counterpart in a seeding amyloid protein assay () called real-time induced conversion () Intermittent shaking is then used to facilitate the interaction between the seed and the substrate to force the monomer to convert into its pathogenThe reaction process is enhanced by the real-time monitoring of thiopentot in sulfur is a typical characteristic of fluorescent dyes combined with amyloid fibers, namely, cross-beta structureThe entire study analyzed patients or other biological fluids or tissuesResults: Virus protein () which was able to identify the wrong-folded form of disease () has a specific ity of % sensitivity to -% and has therefore been included in the diagnostic criteria for the diseaseBy proving that the test can also accurately distinguish with other recent studies of Parkinson's disease or dementia that are not associated with alpha, it can also be successfully applied to synaptic nucleoprotein disease, especially those related to pathologyOriginal link: - Original Source: Original Content Presentation EndStojudged Whether login ends.