Acta Neuropathologica: Transparent cell meningioma is defined as a highly different DNA methylation spectrum and SMARCE1 mutation

Meningoma is the most common primary central nervous system tumor, accounting for about one-third of all brain tumors.
transparent cell meningoma is a rare meningoma that usually affects children and young people.
in histology, it is characterized by round or polygonal transparent cell slices and peripheral and interstational collagen around blood vessels.
transparent cell meningitoma is associated with more aggressive behavior and is therefore classified as a World Health Organization (WHO) Level 2 tumor.
from a genetic point of view, there have been reports that the SMARCE1 gene of this meningoma subshaper encodes the richness of a sub-unit of functionally missing mutations in the SWI/SNF chromatin remodeling complex.
NF2 mutations are common in other meningomas, but are rare in this subsype.
However, it is not clear whether transparent cell meningoma is merely a morphological variant (despite its prognostic significance), whether in principle it can be associated with various driver changes, or whether the advantages of SMARCE1 changes point to a unique set of identified molecular basis for these characteristics is still unknown.
In the study, the team described a molecularly different tumor substation, n-31, which was originally found in 3,093 meningoma queues through genome-wide DNA methylation screening, most of which were histologically diagnosed as transparent cell meningomas.
the queue further analyzed 11 other histologically diagnosed transparent cell meninges (n s 42).
targeted DNA sequencing showed SMARCE1 mutations in 33/34 analysis samples, accompanied by loss of nucleolytic expression determined by immunologic tissue chemistry and reduced expression of SMARCE1 transcripts in tumor cells.
the progression or recurrence times of patients in the transparent cell meningiome group (n-14) and who are in the WHO stage 2 meningoma group (n-220) were similar, which supported the WHO's 2-stage treatment of these meningomas.
above, the results show that transparent cell meningoma has a highly unique epigenetic characteristics, unlike all other variants of meningoma, the SMARCE1 gene has repeated mutations.
suggests that these tumors may come from pregenic cell groups that are different from other meningoma subsypes.
Sievers, P., Sill, M., Blume, C. et al. Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1. Acta Neuropathol (2020). MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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