ACS Nano; Chinese scientists develop selective three metal nano enzyme for the treatment of brain injury

February 17, 2019 news / BIOON / - metal nanoenzymes are widely concerned in biomedicine These enzymes need to have high-efficiency catalytic activity in physiological environment, but at present, the catalytic activity of metal nanoenzymes is not selective, and it is difficult to achieve the selectivity of catalytic activity, which limits the application of metal nanoenzymes Photo source: in order to solve this problem, researchers from Tianjin University, Chinese Academy of Medical Sciences and Peking Union Medical College have developed a kind of three metal (trim) nano enzyme, which has high catalytic activity and environmental selectivity Relevant research results were recently published in ACS Nano, entitled: redox ternary Nanozyme with NeutralEnvironment Preference for Brain Injury。 Through the enzyme simulation experiment, the researchers found that the trim system has a variety of enzyme activities to remove reactive oxygen species (ROS) and reactive nitrogen species (RNs) More importantly, the enzyme system tends to scavenge · o, 1O2 and · no radicals in neutral environment, which indicates that the enzyme has high catalytic selectivity Through density functional theory (DFT) calculation, the researchers found that the enzyme can easily capture electrons in neutral environment and provide enough attraction to combine ROS and RNs In vitro experiments showed that the enzyme could significantly improve the activity of injured neurons In vivo experiments, the researchers found that the activity of superoxide dismutase (SOD) and the level of lipid peroxidation in the brain were restored to a large extent after LPS induced brain injury model was treated with this enzyme In addition, the use of trim nano enzyme treatment can also significantly improve the survival rate, neuroinflammation and memory of mice In general, this new study provides a new way to improve the activity selectivity of nano enzyme in the physiological environment, and explores the application of this selective nano enzyme in the field of brain neuroscience Reference: Xiao Dong Zhang et al Redox ternary nanozyme with neutralenvironment preference for brain intervention ACS Nano Doi: 10.1021/acsnano.8b08045