Accurately remove tiny tumors! Fudan University has made important progress together.

(Health Times Web reporter Wei Wei)
" Current surgical removal of tumors is still the most effective treatment. However, in many invasive or metastatic cancers, the boundaries of the tumor are not clearly distributed and even experienced surgeons are unable to surgically remove the tumor simply, and these small remaining small tumors can cause fatal tumor recurrence and metastasis. Professor Lu Wei, of Fudan University's School of Pharmacy, said it was crucial to treat cancer by detecting and removing these remaining micro-lesions during surgery.
recently, Fudan University School of Pharmacy Professor Lu Wei and Shanghai Jiaotong University School of Medicine Professor Xiao Zeyu's team reported a new type of albumin-near-infrared II region small molecule composition of the integrated preparation, can be used to use near-infrared II region optical imaging technology, to achieve in the surgery to identify tumor primary and micrometrial lesions, while under the guidance of the image to play a photothermal therapy role, completely and accurately remove small tumors, to avoid the recurrence of tumors. The findings were published online in Nature Communications.
it is known that inoperative fluorescence imaging has the advantages of high resolution and rapid imaging, which can guide surgeons to more clearly divide small tumors with normal tissues during surgery. However, the excitation and emission wavelengths of the inoperative fluorescent probes currently used in clinical use are in the visible light range, the imaging depth is limited, and the tissue spontaneous fluorescence interferes strongly.
for this purpose, the Fudan University Joint Task Force explored the discovery of a small molecular fluorescence probe that can be imaged at the wavelength of the near-infrared ii region (1000 nm to 1400 nm). The near-infrared fluorescent probe molecular imaging depth is deeper, the background interference is low, it also has the absorption of light energy into heat and produce thermal heat conversion performance, can be achieved in the operation of detected small tumors photothermal therapy, thereby killing tumor cells.
experimental group modeled on mice in situ colon cancer microtumor, the albumin-near-infrared area of small molecule diagnosis and treatment preparation can achieve 0.5 mm x 0.3 mm micro-metastatic tumor in the operation of clear fluorescence imaging, and not subject to intestinal content fluorescence interference; This study opens up new research ideas and methods for the clinical transformation of the technology of real-time detection and photothermal removal of microtumors in surgery.
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