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AACR 2021: NX-1607 in the treatment of colorectal cancer and triple-negative breast cancer, the preclinical research results are significant

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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The biopharmaceutical company Nurik Therapeutics announced today that it will announce the preclinical data of its NX-1607 at the 2021 annual meeting of the American Association for Cancer Research.

Lymphoma, Colorectal Cancer, Breast Cancer ⁺

The E3 ubiquitin ligase CBL-B is expressed in T cells, where it plays an important role as a negative regulator of immune activation.

Immunity ⁺⁺

NX-1607 can stimulate human immune cells at low nanomolar concentrations.

NX-1607 showed significant tumor growth inhibitory effect in two colon cancer tumor models CT26 and MC38 and triple negative breast tumor model 4T1.

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