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A study published online recently in the British journal "Nature" shows that an amino acid called valine plays a key role in the development of acute T lymphoblastic leukemia, and it is hoped that this leukemia will be treated through dietary modification in the future
Acute lymphoblastic leukemia is a malignant disease in which B- or T-lineage cells originating from lymphocytes proliferate abnormally in the bone marrow
New York University researchers found that genes involved in the depletion of intracellular valine were more active in leukemia cells -- abnormally proliferating T lymphocytes -- than in normal T lymphocytes
The researchers transplanted leukemia cells from human bone marrow into experimental mice to develop acute T-lymphoblastic leukemia
The researchers plan to test a diet low in valine in leukemia patients next year to see if the diet can reduce leukemia cells to very low levels, which can then be combined with leukemia drugs to stop the disease from progressing