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Researchers in Japan have successfully used pyrrolizidine alkaloids to inhibit the growth
of cancer cells.
Pyrroline lizidine alkaloids are found in about 6,000 plant species, including the daisy family and the legume family
.
"The problem of toxicity to the liver is inseparable from the active mechanism of the pyrrolizidine alkaloid,"
explains lead author Professor Satoshi Yokoshima.
Professor Yokoshima of the Graduate School of Pharmacology at Nagoya University, together with Professor Katsunori Tanaka from Tokyo Institute of Technology and the Japan Institute of Physics and Chemistry, studied the possibility of
inhibiting the proliferation of cancer cells without toxicity.
"I am interested in the structure of natural products," explains Professor Yokoshima
.
To introduce the gold catalyst into the human body, the team turned to Professor Tanaka of the Japan Institute of Physics and Chemistry, who had supported the gold catalyst
on a protein albumin in the blood.
The team confirmed the conversion to an active form
containing a pyrrole structure.
"Pyrrolizidine alkaloids are toxic to the liver, but this method avoids toxicity," Professor Yokoshima said
.
This research is supported by the Japan Medical Research and Development Agency (AMED) under the "Fundamental Projects Supporting Life Sciences and Drug Discovery Research (bindings)" and "Basic Technology Development for Advanced Biotechnology Drug Discovery" and the "Translational Chemistry and Bioinformatics Graduate Program (GTR)" of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
.
The project is supported
by the Mexican Ministry of Science and Technology "Development of Basic Technologies for Advanced Biopharmaceutical Drug Discovery" and the "Graduate Program for Translational Chemistry and Biotechnology Research (GTR)".
essay
The hepatotoxicity mechanism of pirolicidine alkaloids was investigated by glycosylated artificial metallas
