A sedentary lifestyle and sugary diet are more harmful to men

A new study from the University of Missouri School of Medicine demonstrates for the first time that short-term lifestyle changes disrupt blood vessels' response
to insulin.
It was also the first study
to show that men and women responded differently to these changes.

Vascular insulin resistance is a feature of obesity and type 2 diabetes and can lead to vascular disease
.
The researchers examined vascular insulin resistance in 36 young, healthy men and women by asking them to cut back on physical activity for 10 days, reducing their steps per day from 10,000 to 5,000
.
Participants also increased their intake of sugar-sweetened beverages to 6 cans of soda
per day.

Camila Manrique-Acevedo, MD, associate professor of medicine, said: "We know that premenopausal women have lower rates of insulin resistance and cardiovascular disease compared to men, but we wanted to see how men and women respond
to reduced physical activity and increased sugar in their diets over a short period of time.
"

The results showed that only in men, a sedentary lifestyle and high sugar intake led to a decrease in insulin-stimulated leg blood flow and a decline in a protein called adropin, which regulates insulin sensitivity and is an important biomarker of
cardiovascular disease.

Manrique-Acevedo said: "These findings highlight sex differences
in the development of vascular insulin resistance caused by lifestyles high in sugar and low exercise.
" "To our knowledge, this is the first evidence that vascular insulin resistance can be triggered by short-term adverse lifestyle changes, and it is the first literature
on sex differences in the development of vascular insulin resistance associated with changes in adropin levels.
"

Manrique-Acevedo says her next step is to study how long it takes to reverse these vascular and metabolic changes and to assess more fully the role of
sex in the development of vascular insulin resistance.

The entire University of Michigan research team consists of Dr.
Jaume Padilla, associate professor of nutrition and exercise physiology and co-corresponding author of the work; Luis Martinez-Lemus, Ph.
D.
, Professor of Medical Pharmacology and Physiology, and R.
Scott Rector, Ph.
D.
, Associate Professor of
Nutrition.
Also included is postdoc Dr.
Rogerio Soares; and graduate students James A.
Smith and Thomas M.
Jurrissen
。

Their study, "Young Women Can Prevent Vascular Insulin Resistance Caused by an Obese Sexual Lifestyle," was recently published in the Journal of
Endocrinology.
This research was supported
in part by the National Institutes of Health and Veterans Scholarships.
The content does not necessarily represent the official views of
the funding agency.
The authors declare no potential conflicts of
interest.

Manrique-Acevedo and her collaborators work at MU's Roy Blunt Next Generation Precision Health Building, a statewide initiative to unite government and industry leaders with innovators from the system's four research universities in pursuit of life-changing precision health advancements
.
The University of Missouri System's Bold Next Generation initiative underscores the promise of personalized healthcare and the impact
of massive interdisciplinary collaboration.

Journal Reference:

1. James A Smith, Rogerio N Soares, Neil J McMillan, Thomas J Jurrissen, Luis A Martinez-Lemus, Jaume Padilla, Camila Manrique-Acevedo.
   Young Women Are Protected Against Vascular Insulin Resistance Induced by Adoption of an Obesogenic Lifestyle.
   Endocrinology, 2022; 163 (11) DOI: 10.
   1210/endocr/bqac137