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A&R: The role of genetics in the development of clinically suspected arthralgia and rheumatoid arthritis, a large cross-sectional study

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Objective: To investigate whether established genetic predictors of rheumatoid arthritis (RA) differ between healthy controls (HC) and clinically suspected arthralgia (CSA.

Methods: Using ANOVA, χ ² test and analysis of mean/risk difference, the associations of RA polygenic risk score (PRS) and HLA-SE with all participating groups, including non-stratified and stratified anticitrullinated protein, were investigated Antibody (ACPA) statu.

Three disjoint datasets from the same Dutch population were used: 1015 HC patients, 479 CSA patients and 1146 RA patient.

Results: Compared with CSA [mean (standard deviation): 07 (94)] and CSAc [12 (1994)], PRS was increased in RA patients [31 (96).

HLA-SE was more prevalent in RA (Pre.

CONCLUSIONS: This study observed increased genetic susceptibility in the (ex) RA participant population; RA-PRS differed even in both ACPA strata in early diagnosed RA and in the pre-inflammatory phas.

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https://onlinelibrar.

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