 Home > Active Ingredient News > Immunology News > A&R: Small-molecule inhibitors of nuclear export improve lupus by modulating plasma cell production and survival

A&R: Small-molecule inhibitors of nuclear export improve lupus by modulating plasma cell production and survival

 Last Update: 2022-09-06
 Source: Internet
 Author: User

Tags

composite cell

anti drug antibodies

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

OBJECTIVE: To investigate the hypothesis that recently approved selective inhibitors of nuclear export (SINE compounds) for the treatment of refractory plasma cell (PC) malignancies may have potential in the treatment of lupus

Methods: Female NZB/NZW mice were treated with the SINE compound KPT-350 or vehicle control

RESULTS: KPT-350 abolished murine lupus nephritis in the early and late stages of the disease and rapidly impaired the generation of autoreactive plasma cells in the germinal center (GC)

Conclusions: Collectively, the team's findings provide support for the therapeutic potential of selective nuclear export inhibitor compounds as they target several molecular and cellular pathways critical in lupus pathogenesis, including plasma cells produced autoantibodies

Source: Rangel-Moreno, J.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

High Purity 99% BPN14770 Zatolmilast 1606974-33-7 In Stock Fast Ship to USA

CAS No.: 1606974-33-7

Pharm Grade

$1-1.1/UNIT FOB

High quality Thymosin α1 Pure CAS 62304-98-7 Thymosin Alpha 1 Thymalfasin

CAS No.: 62304-98-7

Pharmacy Grade

$12-15/UNIT FOB

Top quantity Imiquimod CAS NO 99011-02-6 White crystalline powder 99% API

CAS No.: 99011-02-6

Pharmacy Grade

$1800-1850/KG FOB

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.