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A&R: B-cell reconstitution strongly associated with COVID-19 vaccine responsiveness in rheumatic patients receiving rituximab

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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OBJECTIVE: To assess the association between detectable antibody responses to COVID-19 vaccination and factors such as B -cell depletion in patients receiving rituximab (RTX.

OBJECTIVE: To assess the association between detectable antibody responses to COVID-19 COVID-19 vaccination and factors such as B -cell depletion in patients receiving rituximab (RTX) therap.

Methods: We performed a retrospective review of cases of adult patients who received RTX and completed SARS-CoV-2 messenger RNA vaccinati.

RESULTS: Among the 56 patients treated with RTX , a significant difference in the level of B cell reconstitution was observed in seropositive patients compared with vaccinated seronegative patients (the proportion of B cells in total lymphocyte.

Conclusions: B -cell reconstitution and longer time since the patient's last exposure to RTX were associated with positive serological responses to the COVID-19 vaccin.

Source: Jinich,.

Jinich,.
, Schultz,.
, Jannat-Khah,.
and Spiera,.
(2022), B Cell Reconstitution Is Strongly Associated With COVID-19 Vaccine Responsiveness in Rheumatic Disease Patients Who Received Treatment With Rituxim.
Arthritis Rheumatol, 74: 776-78https://d.
org/11002/a.
42034 https://d.
org/11002/a.
42034Comment here

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