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A&R: Assessment of immune cell subsets and genetic mutations in rheumatoid factor- and anti-citrulline antibody-negative patients with striated rheumatism

 Last Update: 2022-08-15
 Source: Internet
 Author: User

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Objective: The etiology of rheumatoid factor and anti-CCP-negative striated rheumatism is not associated with other rheumatic diseases (seronegative P.

Rheumatoid factor anti-CCP negative striated rheumatism striated rheumatism immune cells and genes immune cells and genes

Methods: A single-center comparative study was performed on 48 seronegative PR patients and 48 healthy subjec.

Single Center Comparative Study Flow Cytometry RNA Sequencing Whole Exome Sequencing (WES)

Results: Compared with the control group, the frequency of CD14+CD11b+CD36+ and CD4+CD25-CD69+ cells in active PR patients was significantly increased (both p<000

Inflammation/stress response, phagocytosis and apoptosis regulation

Upregulation of CXCL16 and IL-10RA was observed in PR monocyt.

WES revealed novel polygenic mutations in HACL1, KDM5A, RASAL1, HAVCR2, PRDM9, MBOAT4, and JR.

CONCLUSION: In seronegative PR patients, a distinct CD14+CD11b+CD36+ subset was found, which can induce inflammatory responses under stress and exert anti-inflammatory effects after phagocytosis of apoptotic cel.

CD14+CD11b+CD36+ subset CD14+CD11b+CD36+ subset CD4+CD25-CD69+ CD4+CD25-CD69+

Individuals with genetic mutations involved in epigenetic modifications , enhancement and elimination of stress-induced inflammation/apoptosis, and dysregulated ER stress responses may predispose to seronegative PR

Epigenetic modifications enhance stress-induced inflammation/apoptosis and abolish dysregulated ER stress response seronegative PR

Source:

Yang CA, Li JP, Lai YH, et .

Yang CA, Li JP, Lai YH, et .
Assessing the immune cell subset and genetic mutations in palindromic rheumatism negative for rheumatoid factor and anti-citrullinated antibodies [published online ahead of print, 2022 Jul 1
Arthritis Rheumat.
2022;11002 /a.
4229 doi:11002/a.
42297 Leave a message here

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