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A&R: A Mendelian randomization study of telomere length and the development of systemic lupus erythematosus

 Last Update: 2022-08-15
 Source: Internet
 Author: User

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OBJECTIVE: Previous observational studies have shown that leukocyte telomere length (TL) is significantly shorter in patients with systemic lupus erythematosus (SLE.

Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus (SLE) Telomere Length (TL) Telomere Length (TL)

Methods: Two-sample Mendelian randomization analysis (TSMR) was used to assess the causal relationship of TL to SLE in European populations, and a replicated TSMR study was performed using Asian genetic da.

Two-sample Mendelian randomization (TSMR) reverse MR autoantibodies (TERF1 autoantibodies)

RESULTS: Inverse variance-weighted results (OR=96, 95%CI 58-55, P<001) showed a causal relationship between longer TL and SLE risk in populations of European ancest.

Conclusions: Compared with previous observational studies, MR analysis found that longer TL was associated with higher risk of SLE

MR analysis found that the longer the TL, the higher the risk of SLE The MR analysis found that the longer the TL, the higher the risk of SLE

Source:

Wang XF, Xu WJ, Wang FF, et .

Wang XF, Xu WJ, Wang FF, et .
Telomere length and development of systemic lupus erythematosus: a Mendelian randomization study [published online ahead of print, 2022 Jul 1
Arthritis Rheumat.
2022;11002/a.
4230 doi: 11002/a.
42304 leave a message here

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