A protein in eggs may be related to infertility
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Last Update: 2018-02-26
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Source: Internet
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Author: User
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A protein in the eggs of female mice determines whether they can bear or not, and human beings also have this protein, which is expected to find a reason for some female infertility, scientists reported in the journal development cell The researchers bred 10 mice that lacked L2 protein in their eggs and 10 normal mice In 6 months, about 60 pups were born in the normal mice group, while those without L2 protein could not Mice lacking L2 protein looked normal, but could not fertilize The researchers found that L2 protein in the egg is responsible for terminating the transcription of deoxyribonucleic acid (DNA) into messenger RNA (mRNA) at the final stage of egg development, allowing the egg to "quietly" wait for conception, a process known as "global transcriptional silencing" But without L2, the process will not be stopped, and the egg will not be fertilized and developed into an embryo Heidi cook Anderson, an assistant professor at the University of California, San Diego, said that many couples in the clinic have normal results in all tests, but it is difficult to find the cause of infertility The study provides a clue "Many research groups look at gene regulation from the perspective of gene activation in cells, and now we find that gene closure is equally important." The research team will further study to confirm whether the lack of L2 protein will lead to human infertility.
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