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Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver, is a common disease common in obese people
The liver is an important organ that coordinates the overall metabolism of glucose and fat in the body
To answer this question, Margaret Chan's team examined gene expression in the livers of high-fat diet-induced obese mice and found that a protein called SH3 domain-binding kinase (SBK1) was elevated only in the livers of obese mice
Dr.
In addition to animal studies, Margaret Chan's team used cultured cell models to answer the question of how the SBK1 gene controls lipid metabolism in the liver
To extend their findings to therapeutic applications, the team further tested whether manipulating SBK1 protein activity in the liver could rescue the damage caused by obesity
"Our study clearly shows that the SBK1 protein is an important regulator of lipid metabolism, which was previously overlooked," said Dr.
