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Image: This protein-protein interaction network was constructed by mapping potential targets of food allergy, IgE and mast cell disease to the Strings database
The researchers combined advanced computational methods with experimental studies to gain new insights at the cellular level into how the plant compound formononetin can be used to treat food allergies
Formononetin is found in plants and herbs, such as red clover and mung beans, and has been shown to have cancer-fighting properties
"Our findings suggest that formononetin is a particularly good candidate for the treatment of food allergies," said Ibrahim Musa, a doctoral candidate in pathology, microbiology and immunology at New York Medical College.
Food allergies occur when the immune system sees a food or something in a food as a threat
In previous studies, researchers identified formononetin as a potential treatment for allergies because it reduces IgE production
Once they identified the genes and proteins to target, the researchers validated them with cultured cell lines commonly used in allergy research
"Our study shows that systems pharmacology can be used to predict drug/compound-target interactions," Musa said
Researchers have developed a mouse model of peanut allergy, which they plan to use to study formononetin and identify potential side effects
