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A novel anticancer mechanism of PTEN gene: inhibition of tumor invasion and metastasis by encoding circular RNA circPTEN1

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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gene expression data

process metastasis

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On February 8, 2022, Professor Yin Yuxin's team from Peking University School of Basic Medicine published a research paper titled "circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling" in Molecular Cancer .

identified a circular RNA encoded by the tumor suppressor gene PTEN, named circPTEN1

PTEN (Phosphatase and tensin homolog deleted on chromosome 10) is one of the genes with the highest mutation rate in human tumors.
Tumor database statistics show that there are more than 2700 mutations in PTEN gene in tumors of different tissue origins
.

As one of the most important tumor suppressor genes, small changes in the transcription level and protein synthesis of PTEN gene can have an important impact on tumorigenesis

The PTEN protein with dual lipid and protein phosphatase activities can inhibit tumors through various mechanisms.
Its classic tumor suppressor pathway is to dephosphorylate cytoplasmic PIP3 to PIP2, inhibit the PI3K/AKT pathway, and thereby regulate cell survival, cell proliferation, and blood vessels.
form
etc.

The early research work of Yin Yuxin's team revealed that PTEN in the nucleus can play a tumor suppressor role by regulating the DNA replication process and stabilizing the genome

circPTEN1 binds Smad4 and antagonizes Smad complex formation and nuclear entry

Circular RNA (circRNA) is a type of circular non-coding RNA that is covalently linked and does not have head-to-tail structures at the 3' and 5' ends
.

Studies have revealed that circRNAs are closely related to the occurrence and development of various human tumors, so it is of great significance to further study and clarify the regulatory role and specific mechanisms of circRNAs on the occurrence and development of tumors

Zheng Lin and associate researcher Liang Hui, 2018 graduate students of Peking University School of Basic Medicine, are the co-first authors
.

Prof.

Original link: https://molecular-cancer.

biomedcentral.

(Peking University School of Basic Medicine)

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