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A new method of non-invasive testing! Parkinson's disease and multisystem atrophy can be diagnosed in this way

 Last Update: 2022-09-30
 Source: Internet
 Author: User

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The symptoms of Parkinson's disease (PD) and multiple system atrophy (MSA) are more similar and difficult to diagnose and distinguish between clinical symptoms early
.

Recent studies have found that real-time oscillation induced transformation (RT-QuIC) methods can detect α-synuclein aggregates in brain tissue, cerebrospinal fluid, skin, submandibular glands, and olfactory mucosa in patients with PD or MSA, and can induce more α-synuclein aggregation
as seeds.

Zhu Kasa, a researcher in the Molecular Neurobiology Group of the Institute of Biophysics of the Chinese Academy of Sciences, collaborated with researchers in the Department of Neurology of Peking University First Hospital to analyze 75 PD patients, 18 patients with MSA, and 36 normal control saliva specimens
.

The study demonstrated for the first time that saliva α-synuclein has prion-like inoculation activity
.

The results were published in Movement Disorders under the title Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy
.

The above research was funded by the National Natural Science Foundation of China, the National Key Research and Development Program, Peking University and the State Key Laboratory of Brain and Cognitive Science
.

Saliva RT-QuIC method to detect the inoculation activity of α-synuclein

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